| |
T2DM (%)
|
Non-T2DM (%)
|
Odds ratio (95 CI)
|
P-value
|
|---|
|
rs3480 A/G
| | | | |
|
GG
|
78 (20.7)
|
88 (21.5)
|
1.29 (0.82–2.03)
|
0.26
|
|
AG
|
181 (48.1)
|
186 (45.4)
|
1.34 (0.93–1.94)
|
0.11
|
|
AA
|
117 (31.1)
|
136 (32.2)
|
1.0
|
1.0
|
|
rs1746661 G/T
| | | | |
|
TT
|
27 (7.2)
|
25 (6.8)
|
1.22 (0.64–2.35)
|
0.53
|
|
GT
|
125 (33.5)
|
113 (30.9)
|
1.16 (0.81–1.67)
|
0.40
|
|
GG
|
221 (59.2)
|
228 (62.3)
|
1.0
|
1.0
|
|
rs1298190 A/G
| | | | |
|
GG
|
7 (1.8)
|
10 (2.4)
|
0.54 (0.16–1.76)
|
0.31
|
|
AG
|
85 (22.4)
|
90 (22)
|
1.10 (0.75–1.63)
|
0.60
|
|
AA
|
288 (75.8)
|
309 (75.6)
|
1.0
|
1.0
|
|
rs7246334 A/G
| | | | |
|
GG
|
2 (0.5)
|
1 (0.3)
|
–
|
–
|
|
AG
|
280 (75.3)
|
290 (74.7)
|
–
|
–
|
|
AA
|
90 (24.2)
|
97 (25)
|
–
|
–
|
|
rs1570569 G/T
| | | | |
|
TT
|
25 (6.6)
|
23 (5.6)
|
1.45 (0.72–2.8)
|
0.28
|
|
GT
|
132 (34.7)
|
139 (33.9)
|
1.08 (0.76–1.52
|
0.66
|
|
GG
|
223 (58.7)
|
248 (60.5)
|
1.0
|
1.0
|
-
Note: The genotype distribution of rs3480 (A/G), rs1746661 (G/T), rs1298190 (A/G) rs7246344 (A/G) and rs1570569 (G/T) variants of FNDC5 gene. Genotype frequency differences between T2DM and Non-T2DM were tested for each SNP using Chi-square test. Odds ratios (ORs) and 95 % confidence intervals for genotypes were calculated using multinomial logistic regression analyses considering T2DM as dependent variable adjusted for age, gender and BMI. The most common genotype was used as the reference
- Bold means reference value
