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Table 4 Differences in various metabolic parameters according to FNDC5 gene SNPs

From: SNPs in FNDC5 (irisin) are associated with obesity and modulation of glucose and lipid metabolism in Saudi subjects

  rs3480 A/G rs1746661 G/T
Variables GG AG AA P TT GT GG P
BMI (kg/m2) 27.2 ± 6.4 28.3 ± 6.3 29.6 ± 6.5 0.030* 27.9 ± 6.6 28.2 ± 6.8 28.0 ± 6.1 0.93
Insulin (μIU/mL)# 13.54 ± 7.5 16.1 ± 9.5 15.8 ± 9.2 0.24 16.0 ± 8.4 14.8 ± 8.4 15.6 ± 9.6 0.70
HOMA-IR # 4.8 ± 3.9 5.7 ± 4.6 5.2 ± 3.9 0.17 5.8 ± 4.0 5.1 ± 3.6 5.4 ± 4.6 0.64
Glucose (mmol/l) 7.5 ± 3.5 7.3 ± 3.4 7.2 ± 3.4 0.78 7.8 ± 3.5 7.4 ± 3.4 7.4 ± 3.6 0.92
Total Cholesterol (mmol/l) 5.1 ± 1.1 5.1 ± 1.1 5.3 1 ± 1.1 0.66 5.2 ± 1.1 5.2 ± 1.2 5.2 ± 1.1 0.90
HDL-Cholesterol (mmol/l) 0.87 ± 0.3 0.84 ± 0.3 0.94 ± 0.4‡ 0.015 0.89 ± 0.3 0.85 ± 0.3 0.89 ± 0.3 0.20
Triglycerides (mmol/l) 1.45 ± 0.6 1.55 ± 0.5 1.55 ± 0.58 0.13 1.31 ± 0.5 1.58 ± 0.6 1.53 ± 0.5 0.019*
LDL-Cholesterol (mmol/l) 3.60 ± 0.9 3.55 ± 1.0 3.61 ± 1.0 0.80 3.66 ± 0.8 3.60 ± 1.1 3.57 ± 0.9 0.23
Irisin (μg/ml)# 0.70 ± 0.6 0.63 ± 0.5 0.77 ± 0.7 0.62 0.50 ± 0.3 0.77 ± 0.5 0.89 ± 0.7 0.10
  rs1570569 G/T rs1298190 A/G
Variables TT GT GG P GG AG AA P
BMI (kg/m2) (mmol/l) 28.4 ± 6.4 28.4 ± 6.8 28.3 ± 6.1 0.94 28.3 ± 4.7 27.9 ± 6.2 28.4 ± 6.5 0.62
Insulin (μIU/mL)# 21.1 ± 11.5‡ 14.6 ± 8.2 15.5 ± 9.3 0.029* 14.9 ± 10.1 14.6 ± 8.8 15.8 ± 9.2 0.74
HOMA-IR# 9.5 ± 7.4‡ 5.0 ± 3.6 5.2 ± 4.1 0.002* 3.7 ± 2.1 5.4 ± 4.6 5.4 ± 4.1 0.56
Glucose (mmol/l) 8.0 ± 3.9 7.3 ± 3.3 7.3 ± 3.5 0.93 6.7 ± 2.7 7.7 ± 3.8 7.2 ± 3.4 0.40
Total cholesterol (mmol/l) 5.2 ± 1.2 5.1 ± 1.2 5.2 ± 1.1 0.73 4.8 ± 0.7 5.2 ± 1.0 5.1 ± 1.2 0.54
HDL-Cholesterol (mmol/l) 0.86 ± 0.4 0.84 ± 0 .3 0.90 ± 0.35 0.08 0.85 ± 0.2 0.85 ± 0.2 0.89 ± 0.3 0.67
Triglycerides (mmol/l) 1.44 ± 0.6 1.54 ± 0.6 1.53 ± 0.57 0.54 1.52 ± 0.58 1.51 ± 0.6 1.55 ± 0.5 0.77
LDL-Cholesterol (mmol/l) (mmol/l) 3.66 ± 1.0 3.60 ± 1.1 3.5 ± 0.98 0.85 3.48 ± 0.52 3.57 ± 0.9 3.58 ± 1.0 0.93
Irisin (μg/ml) # 0.41 ± 0.3 0.71 ± 0.6 0.72 ± 0.6 0.016* 0.90 ± 0.6 0.64 ± 0.6 0.70 ± 0.6 0.54
  1. Note: Data were presented as mean ± SD values. #log transformed prior to analysis. Univariate general linear model adjusted for appropriate covariates such as age, gender, BMI and T2DM. “*” indicates significance after Bonferroni correction; “‡” indicates significantly different from both the genotypes. Significance was set at p < 0.05
  2. Bold means significant