Table 1 Summary of compounds, animals, and histological findings
| Â | Number of animals | Â | Liver histopathology | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Compound name | Abbreviation | Dose (mg · kg−1 · day−1) | Duration (days) | Control | Chemicals | Administration | Vehicle control | Fibrosis | Cellular infiltration | Necrosis | Proliferation | Ground glass appearance |
Carbon tetrachloride | CCL4 | 100 | 28 | 5 | 5 | peroral | corn oil | Centrilobular, 5/5 (minimal) | Centrilobular | - | - | - |
Lomustine | LS | 6 | 28 | 5 | 5 | peroral | 0.5Â w/v% methylcellulose | Bile duct, 1/5 (minimal), 3/5 (mild) | Periportal | Midlobular | Bile duct, Kupffer cell | - |
2-Acetamidofluorene | AAF | 300 | 28 | 5 | 5 | peroral | 0.5Â w/v% methylcellulose | negative | Periportal | - | Bile duct, Oval cell | - |
N-Nitrosodiethylamine | DEN | 30 | 28 | 5 | 5 | peroral | 0.5Â w/v% methylcellulose | negative | - | Centrilobular | Bile duct | - |
Ethambutol | ETB | 1000 | 28 | 5 | 5 | peroral | 0.5Â w/v% methylcellulose 0.5Â w/v% | negative | - | Single cell | - | Centrilobular |
Carbon tetrachloride | CCL4 | 100 | 3 | 5 | 5 | peroral | corn oil | negative | Centrilobular | - | - | - |
Lomustine | LS | 6 | 3 | 5 | 5 | peroral | 0.5Â w/v% methylcellulose 0.5Â w/v% | negative | - | - | - | - |