Skip to main content

Table 1 Summary of compounds, animals, and histological findings

From: Plasma lipid profiling of different types of hepatic fibrosis induced by carbon tetrachloride and lomustine in rats

  Number of animals   Liver histopathology
Compound name Abbreviation Dose (mg · kg−1 · day−1) Duration (days) Control Chemicals Administration Vehicle control Fibrosis Cellular infiltration Necrosis Proliferation Ground glass appearance
Carbon tetrachloride CCL4 100 28 5 5 peroral corn oil Centrilobular, 5/5 (minimal) Centrilobular - - -
Lomustine LS 6 28 5 5 peroral 0.5 w/v% methylcellulose Bile duct, 1/5 (minimal), 3/5 (mild) Periportal Midlobular Bile duct, Kupffer cell -
2-Acetamidofluorene AAF 300 28 5 5 peroral 0.5 w/v% methylcellulose negative Periportal - Bile duct, Oval cell -
N-Nitrosodiethylamine DEN 30 28 5 5 peroral 0.5 w/v% methylcellulose negative - Centrilobular Bile duct -
Ethambutol ETB 1000 28 5 5 peroral 0.5 w/v% methylcellulose 0.5 w/v% negative - Single cell - Centrilobular
Carbon tetrachloride CCL4 100 3 5 5 peroral corn oil negative Centrilobular - - -
Lomustine LS 6 3 5 5 peroral 0.5 w/v% methylcellulose 0.5 w/v% negative - - - -