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Table 3 Candidate lipid markers for hepatic fibrosis induced by CCL4 and LS

From: Plasma lipid profiling of different types of hepatic fibrosis induced by carbon tetrachloride and lomustine in rats

Class

Ion

Fatty side chains

CCL4

LS

LPC

LPC(18:0)

18:0

−

↑

LPC

LPC(18:3)

18:3

↓

↑

LPC

LPC(20:4)

20:4

↓

↑

LPC

LPC(22:6)

22:6

↓

↑

PC

PC(34:0)

16:0/18:0

−

↑

PC

PC(36:0)

18:0/18:0

−

↑

PC

PC(36:4)b

16:0/20:4

−

↑

PC

PC(38:4)b

18:0/20:4

−

↑

PC

PC(38:5)

18:1/20:4

−

↑

PC

PC(38:6)a

18:2/20:4

↓

↑

PC

PC(38:6)b

16:0/22:6

−

↑

PC

PC(40:4)

18:0/22:4

−

↑

PC

PC(40:5)

20:1/20:4

−

↑

PC

PC(40:6)b

18:0/22:6

−

↑

PC

PC(40:7)

18:1/22:6

−

↑

PC

PC(40:8)

N.D.

↓

↑

PC

PC(42:7)

N.D.

−

↑

PC

PC(42:10)

20:4/22:6

↓

↑

ePE

PE(38:5e)a

N.D.

−

↑

ePE

PE(38:5e)b

N.D.

−

↑

ePE

PE(40:5e)

N.D.

−

↑

PI

PI(36:4)

16:0/20:4

−

↑

PI

PI(40:6)

18:0/22:6

−

↑

SM

SM(34:1)

N.D.

−

↑

SM

SM(34:2)

N.D.

−

↑

SM

SM(40:2)

N.D.

−

↑

SM

SM(42:2)

N.D.

−

↑

SM

SM(42:4)

N.D.

−

↑

Cer

Cer(42:1)

N.D.

↓

−

TG

TG(54:6)b

16:0/18:2/20:4

−

↑

TG

TG(56:5)

16:0/18:1/22:4

−

↑

TG

TG(56:6)

18:1/18:1/20:4

−

↑

TG

TG(58:6)

18:1/18:1/22:4

−

↑

TG

TG(58:7)

N.D.

−

↑

TG

TG(60:8)

N.D.

−

↑

TG

TG(60:9)

18:1/18:2/24:6, 18:1/20:3/22:5

−

↑

TG

TG(60:10)

N.D.

−

↑

TG

TG(62:11)

N.D.

−

↑

  1. The underline lipid molecules are altered by both CCl 4 and LS. CCl 4 carbon tetrachloride; LS lomustine; LPC lysophosphatidylcholine; PC phosphatidylcholine; ePE ether-type PC, PI phosphatidylinositol; SM sphingomyelin; Cer ceramide; TG triacylglycerol; N.D. not determined