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Table 1 Body weight, glycemic, insulin, adiponectin and inflammatory parameters at baseline and after 6 months of dietary intervention

From: Effects of sardine-enriched diet on metabolic control, inflammation and gut microbiota in drug-naïve patients with type 2 diabetes: a pilot randomized trial

 

Baseline

 

6 Months

  
 

Sardine group (n = 19)

Control group (n = 16)

 

Sardine group (n = 17)

Control group (n = 15)

   
   

P valuea

  

P value b

P within SG c

P within CG c

Md/Fe (n)

8/11

8/8

0.64

7/10

7/8

0.76

  

Age (years)

60.0 ± 1.7

61.2 ± 2.4

0.83

58.7 ± 1.7

59.8 ± 1.9

0.66

  

Weight (kg)

81.7 ± 3.7

75.8 ± 2.9

0.25

80.5 ± 3.7

75.1 ± 2.8

0.71

0.08

0.35

BMIf (kg/m2)

30.5 ± 1.0

28.8 ± 0.8

0.39

30.0 ± 1.0

28.5 ± 0.8

0.70

0.08

0.44

HbA1cg (%)

6.8 ± 0.1

6.7 ± 0.1

0.59

6.6 ± 0.1

6.4 ± 0.1

0.57

0.08

0.01

Fasting glucose (mg/dL)

138.2 ± 6.5

134.3 ± 5.1

0.99

128.6 ± 4.4

129.1 ± 5.4

0.74

0.18

0.36

Fasting insulin (mU/L)

17.2 ± 1.7

15.1 ± 1.8

0.45

11.1 ± 1.8

11.7 ± 2.4

0.37

0.01

0.02

HOMA-IRh

5.9 ± 0.7

5.0 ± 0.6

0.46

3.6 ± 0.6

3.9 ± 0.9

0.34

0.007

0.04

hs-CRPi (mg/dL)

0.2 ± 0.0

0.2 ± 0.1

0.88

0.2 ± 0.0

0.2 ± 0.1

0.73

0.89

0.53

Total adiponectin (μg/mL)

2.1 ± 0.3

2.0 ± 0.4

0.37

3.0 ± 0.3

2.5 ± 0.4

0.26

0.04

0.16

TNFαj (pg/mL)

5.6 ± 0.2

4.9 ± 0.3

0.44

5.6 ± 0.4

6.1 ± 0.5

0.33

0.71

0.05

IL-6k (pg/mL)

3.5 ± 0.3

3.0 ± 0.3

0.66

3.6 ± 0.4

3.3 ± 0.4

0.91

0.68

0.58

IL-8l (pg/mL)

23.3 ± 3.3

18.7 ± 3.0

0.97

25.3 ± 5.3

18.9 ± 1.3

0.50

0.88

0.91

IL-10m (pg/mL)

1.3 ± 0.1

1.2 ± 0.0

0.28

1.5 ± 0.1

1.3 ± 0.1

0.31

0.09

0.12

  1. Values are mean ± SE
  2. a Intergroup comparisons at baseline by Mann-Whitney’s U test or X 2
  3. b Differences between groups at 6 months adjusted for baseline values (ANCOVA)
  4. c Intragroup comparisons by Wilcoxon signed-rank test
  5. d M: male
  6. e F: female
  7. f BMI: Body Mass Index
  8. g HbA1c: glycated hemoglobin
  9. h HOMA-IR: homeostasis model of assessment - insulin resistance
  10. i hs-CRP: high-sensitivity C-reactive protein
  11. j TNFα: tumor necrosis factor alpha
  12. l IL-6: interleukin 6
  13. l IL-8: interleukin 8
  14. m IL-10: interleukin 10