Table 2 Mean ± SD LDL-C levels in 3 different genotypes of the SNPs studied

SORT1

rs646776

GG

2.75 ± 1.00

2.93 ± 1.08

1.98 ± 0.31

2.42 ± 0.60

AG

2.95 ± 1.00

3.49 ± 0.86

2.11 ± 0.55

2.57 ± 0.79

AA

3.13 ± 1.01

3.34 ± 0.95

2.28 ± 0.34

2.88 ± 0.70

β(se)

0.18(0.04)

0.06(0.11)

0.15(0.04)

0.27(0.06)

R²

1.1 %

0.1 %

5.5 %

4.9 %

p-value

8.7x10^-6

0.61

0.002

7.4 × 10^-6

APOB

rs1042031

AA

2.93 ± 0.99

2.40 ± 0

1.67 ± 0.12

2.02 ± 0.09

AG

2.98 ± 0.97

3.36 ± 0.89

2.10 ± 0.42

2.55 ± 0.39

GG

3.10 ± 1.03

3.36 ± 0.97

2.22 ± 0.44

2.78 ± 0.79

β (se)

0.11(0.04)

0.04(0.14)

0.15(0.06)

0.25(0.09)

R²

0.3 %

0.04 %

2.6 %

1.7 %

p-value

0.02

0.79

0.03

0.03

APOE

rs429358 and rs7412

Ɛ2Ɛ2/Ɛ2Ɛ3/Ɛ2Ɛ4

2.67 ± 1.07

3.00 ± 0.86

1.97 ± 0.34

2.30 ± 0.47

Ɛ3Ɛ3

3.10 ± 0.98

3.39 ± 0.93

2.17 ± 0.45

2.69 ± 0.71

Ɛ3Ɛ4/Ɛ4Ɛ4

3.22 ± 0.99

3.45 ± 0.97

2.37 ± 0.35

3.07 ± 0.84

β(se)

0.26(0.04)

0.19(0.11)

0.20(0.06)

0.38(0.07)

R²

2.7 %

1.6 %

5.2 %

7.0 %

p-value

2.6×10^-12

0.08

0.003

7.5 × 10^-8

Ɛ3Ɛ3 vs. Ɛ4Ɛ4 β(se)

0.43(0.06)

0.39(0.21)

0.19(0.11)

0.39(0.14)

p-value

2.1×10^-12

0.06

0.07

0.004

Ɛ3Ɛ3 vs. Ɛ2Ɛ2 β (se)

-0.11(0.06)

-0.07 (0.15)

-0.20 (0.08)

-0.38(0.09)

p-value

0.05

0.67

0.009

0.00004