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Table 2 Mean ± SD LDL-C levels in 3 different genotypes of the SNPs studied

From: Effect of SORT1, APOB and APOE polymorphisms on LDL-C and coronary heart disease in Pakistani subjects and their comparison with Northwick Park Heart Study II

Gene SNP Genotype NPHSII non CHD NPHSII CHD Pakistani non CHD Pakistani CHD
SORT1 rs646776 GG 2.75 ± 1.00 2.93 ± 1.08 1.98 ± 0.31 2.42 ± 0.60
AG 2.95 ± 1.00 3.49 ± 0.86 2.11 ± 0.55 2.57 ± 0.79
AA 3.13 ± 1.01 3.34 ± 0.95 2.28 ± 0.34 2.88 ± 0.70
β(se) 0.18(0.04) 0.06(0.11) 0.15(0.04) 0.27(0.06)
R2 1.1 % 0.1 % 5.5 % 4.9 %
p-value 8.7x10-6 0.61 0.002 7.4 × 10-6
APOB rs1042031 AA 2.93 ± 0.99 2.40 ± 0 1.67 ± 0.12 2.02 ± 0.09
AG 2.98 ± 0.97 3.36 ± 0.89 2.10 ± 0.42 2.55 ± 0.39
GG 3.10 ± 1.03 3.36 ± 0.97 2.22 ± 0.44 2.78 ± 0.79
β (se) 0.11(0.04) 0.04(0.14) 0.15(0.06) 0.25(0.09)
R2 0.3 % 0.04 % 2.6 % 1.7 %
p-value 0.02 0.79 0.03 0.03
APOE rs429358 and rs7412 Ɛ2Ɛ2/Ɛ2Ɛ3/Ɛ2Ɛ4 2.67 ± 1.07 3.00 ± 0.86 1.97 ± 0.34 2.30 ± 0.47
Ɛ3Ɛ3 3.10 ± 0.98 3.39 ± 0.93 2.17 ± 0.45 2.69 ± 0.71
Ɛ3Ɛ4/Ɛ4Ɛ4 3.22 ± 0.99 3.45 ± 0.97 2.37 ± 0.35 3.07 ± 0.84
β(se) 0.26(0.04) 0.19(0.11) 0.20(0.06) 0.38(0.07)
R2 2.7 % 1.6 % 5.2 % 7.0 %
p-value 2.6×10-12 0.08 0.003 7.5 × 10-8
Ɛ3Ɛ3 vs. Ɛ4Ɛ4 β(se) 0.43(0.06) 0.39(0.21) 0.19(0.11) 0.39(0.14)
p-value 2.1×10-12 0.06 0.07 0.004
Ɛ3Ɛ3 vs. Ɛ2Ɛ2 β (se) -0.11(0.06) -0.07 (0.15) -0.20 (0.08) -0.38(0.09)
p-value 0.05 0.67 0.009 0.00004
  1. β (se): beta effect which is increase or decrease (mmol/L) in LDL-C per risk allele along with standard error of mean. R2 = proportion of sample variance in LDL-C