The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio as a predictor of insulin resistance but not of β cell function in a Chinese population with different glucose tolerance status

Zhou, Meicen; Zhu, Lixin; Cui, Xiangli; Feng, Linbo; Zhao, Xuefeng; He, Shuli; Ping, Fan; Li, Wei; Li, Yuxiu

doi:10.1186/s12944-016-0270-z

Lipids in Health and Disease

Table 1 Characteristics in different glucose tolerance status

From: The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio as a predictor of insulin resistance but not of β cell function in a Chinese population with different glucose tolerance status

Characteristic	NGT	Pre-diabetes	Diabetes	P-value
Characteristic	N = 192	N = 186	N = 101	P-value
Female (%)	135 (70.31)	115 (61.83)	60 (59.41)	0.000*
Age, years	48.77 ± 11.55	55.36 ± 10.22	54.54 ± 9.89	0.000*
BMI, kg/m²	24.98 ± 3.46	26.74 ± 3.74	26.86 ± 4.15	0.000*
Overweight/obesity (%)	114 (59.38)	136 (73.12)	80 (79.21)	0.000*
Waist circumference, cm	84.64 ± 9.75	88.48 ± 9.19	88.31 ± 9.54	0.000*
Hip circumference, cm	90.17 ± 9.88	93.52 ± 8.88	93.13 ± 12.26	0.003*
Systolic BP, mm Hg	123.59 ± 19.08	129.12 ± 15.92	131.45 ± 20.89	0.001*
Diastolic BP, mm Hg	75.54 ± 9.93	76.50 ± 10.02	77.06 ± 10.76	0.429
HbA1c	5.26 ± 0.29	5.71 ± 0.33	6.87 ± 1.42	0.000*
Fasting plasma glucose (PG), mmol/L	5.45 ± 0.35	6.09 ± 0.48	8.48 ± 2.77	0.000*
PG 30’, mmol/L	8.96 ± 1.93	10.71 ± 2.01	14.78 ± 3.97	0.000*
PG 60’, mmol/L	7.57 ± 1.98	10.09 ± 2.82	16.73 ± 4.92	0.000*
PG 120’, mmol/L	5.86 ± 1.18	7.61 ± 1.76	14.92 ± 5.79	0.000*
Ln (Ins 0’, mU/L)	2.19 ± 0.49	2.31 ± 0.51	2.40 ± 0.65	0.004*
Ln (Ins 30’, mU/L)	4.28 ± 0.67	4.19 ± 0.65	3.65 ± 0.83	0.000*
Ln (Ins 60’, mU/L)	4.09 ± 0.66	4.29 ± 0.69	4.05 ± 0.90	0.008*
Ln (Ins 120’, mU/L)	3.44 ± 0.72	3.87 ± 0.78	3.96 ± 0.96	0.000*
Ln (C peptide 0’, ng/mL)	0.18 ± 0.36	0.36 ± 0.39	0.40 ± 0.48	0.000*
Ln (C peptide 30’, ng/mL)	1.63 ± 0.42	1.57 ± 0.42	1.15 ± 0.59	0.000*
Ln (C peptide 60’, ng/mL)	1.74 ± 0.44	1.84 ± 0.90	1.58 ± 0.61	0.000*
Ln (C peptide 120’, ng/mL)	1.47 ± 0.42	1.76 ± 0.44	1.71 ± 0.63	0.000*
InsAUC₃₀/GluAUC₃₀ (mU/mmol)	6.84 ± 2.36	5.72 ± 2.41	3.11 ± 1.72	0.000*
InsAUC₁₂₀/GluAUC₁₂₀ (mU/mmol)	8.39 ± 2.77	9.21 ± 2.02	5.04 ± 2.38	0.000*
Ln HOMA-IR	0.79 ± 0.46	1.02 ± 0.50	1.38 ± 0.68	0.000*
Sqrt HOMA-β	9.99 ± 2.55	9.20 ± 2.43	7.68 ± 2.86	0.000*
Sqrt DI₃₀	24.91 ± 4.90	19.58 ± 4.64	11.97 ± 4.18	0.000*
Sqrt DI₁₂₀	27.91 ± 3.84	23.39 ± 6.78	15.06 ± 6.01	0.000*
Ln [(ΔIns₃₀/ΔGlu₃₀)/HOMA-IR]	2.32 ± 0.78	1.76 ± 0.71	0.85 ± 0.59	0.000*
Total cholesterol (TC), mmol/L	5.26 ± 1.04	5.64 ± 1.01	5.61 ± 0.97	0.001*
Log (triglyceride [TG]), mmol/L	0.09 ± 0.27	0.20 ± 0.24	0.26 ± 0.26	0.000*
Log (HDL-C, mmol/L)	0.11 ± 0.10	0.10 ± 0.10	0.08 ± 0.09	0.013*
LDL-C, mmol/L	2.67 ± 0.74	2.96 ± 0.69	2.91 ± 0.66	0.000*
Log (TG/HDL-C)	−0.02 ± 0.32	0.10 ± 0.29	0.18 ± 0.30	0.000*
TC/HDL-C	4.08 ± 1.02	4.50 ± 0.91	4.66 ± 0.85	0.000*
LDL-C/HDL-C	2.09 ± 0.71	2.37 ± 0.64	2.43 ± 0.60	0.000*

* Significant results: p < 0.05

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