Fig. 3

Increased protein synthesis following a surge of energy substrates with concomitant rise in reactive oxygen species. Our proteomic analysis suggests that increased energy substrates instigates processes that limit lipotoxicity potentially to curb oxidative stress. This involves diversion towards non-oxidative pathways with concomitant rise in the efflux of lipid from the liver. The associated changes in histones are most likely to represent an adaptation to increased transcription but whether such alterations can increase DNA susceptibility to further oxidative stress damage should be explored