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Table 5 Changes in biochemical parameters after 16 weeks of supplementation

From: Efficacy and tolerability of Meratrim for weight management: a randomized, double-blind, placebo-controlled study in healthy overweight human subjects

Parameter

Placebo

Meratrim

P value

(n = 28)

(n = 29)

Liver function

 SGOT (U/L)

−1.89 ± 0.83

−1.66 ± 0.97

0.2999

 SGPT (U/L)

−2.22 ± 0.85

−3.65 ± 0.94

0.0181

Renal function

 BUN (mg/dL)

−1.48 ± 0.26

−1.65 ± 0.29

0.1938

 Creatinine (mg/dL)

−0.15 ± 0.03

−0.15 ± 0.03

0.7998

Metabolic panel

 Triglycerides (mg/dL)

−13.68 ± 5.17

−43.62 ± 6.74

<0.001*

 Cholesterol (mg/dL)

−0.75 ± 5.10

−20.00 ± 2.88

0.0002*

 LDL (mg/dL)

6.25 ± 4.79

−14.79 ± 2.93

<0.0001*

 HDL (mg/dL)

-1.96±0.48

2.03±0.75

<0.0001*

 LHR

0.35 ± 0.14

−0.49 ± 0.11

<0.0001*

 VLDL (mg/dL)

−5.04 ± 1.16

−7.24 ± 1.08

0.011*

 Fasting glucose (mg/dL)

−10.64 ± 2.05

−9.41 ± 1.13

0.8926

  1. Values represent mean ± SE
  2. BUN Blood Urea Nitrogen, SGOT Serum Glutamic Oxaloacetic Transaminase; SGPT Serum Glutamic-Pyruvic Transaminase; LDL low-density lipoproteins; HDL high-density lipoprotein; LHR LDL/HDL ratio; VLDL very low-density lipoproteins
  3. *Significant difference between Meratrim and placebo group mean values calculated using ANCOVA with baseline as covariate