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Table 2 Multivariable linear regression analysis showing associations of plasma phospholipid transfer protein (PLTP) activity (A) and lecithin:cholesterol acyltransferase (LCAT) activity (B) as dependent variables with clinical variables, (apo)lipoproteins and betaine as statistical determinants

From: Plasma phospholipid transfer protein activity is inversely associated with betaine in diabetic and non-diabetic subjects

 

Model 1

Model 2

β

p-value

β

p-value

A. PLTP activity

 Age

0.076

0.37

0.078

0.36

 Sex (men/women)

−0.139

0.14

−0.163

0.07

 Diabetes (yes/no)

0.340

<0.001

0.339

<0.001

 BMI

0.176

0.06

0.181

0.043

 Non-HDL cholesterol

0.126

0.22

  

 HDL cholesterol

0.064

0.59

  

 Triglycerides

0.146

0.232

  

 Apolipoprotein B

  

0.166

0.05

 Apolipoprotein A-I

  

−0.014

0.88

 Betaine

−0.179

0.034

−0.204

0.014

B. LCAT activity

 Age

0.007

0.92

−0.003

0.97

 Sex (men/women)

0.004

0.96

−0.006

0.95

 Diabetes (yes/no)

0.186

0.018

0.188

0.034

 BMI

0.154

0.053

0.217

0.013

 Non-HDL cholesterol

0.344

<0.001

  

 HDL cholesterol

0.304

0.003

  

 Triglycerides

0.505

<0.001

  

 Apolipoprotein B

  

0.490

<0.001

 Apolipoprotein A-I

  

0.198

0.033

 Betaine

−0.056

0.44

−0.130

0.10

  1. β standardized regression coefficients, BMI body mass index, HDL high density lipoproteins. Triglycerides levels are logarithmically transformed
  2. Model 1: includes age, sex, diabetes status, BMI, plasma non-HDL cholesterol, HDL cholesterol, triglycerides and betaine as independent variables
  3. Model 2: includes age, sex, diabetes status, BMI, apolipoprotein B, apolipoprotein A-I and betaine as independent variables