Skip to main content

Table 1 Pharmacokinetic parameters of vincristine sulphate after intravenous administration of 0.15 mg/kg solution in normolipidemic (NL), intermediate hyperlipidemic (IHL), and extreme hyperlipidemic (HL) rats

From: The effect of increased lipoproteins levels on the disposition of vincristine in rat

  NL IHL HL
Co (mg/L) 1.03 ± 0.50 0.50 ± 0.29 0.99 ± 0.76
AUC0–∞ (mg.h/L) 4.20 ± 3.23 2.25 ± 0.67 3.72 ± 1.38
λz (h-1) 0.06 ± 0.03 0.03 ± 0.01 0.04 ± 0.03
t ½ (h) 14.6 ± 7.62 30.3 ± 11.6 28.2 ± 18.3
CL/kg (L/h/kg) 0.06 ± 0.04 0.07 ± 0.02 0.05 ± 0.02
Vβ/kg (L/kg) 1.53 ± 1.80 2.88 ± 0.52 1.74 ± 1.15
Vc/kg (L/kg) 0.17 ± 0.08 0.39 ± 0.21 0.27 ± 0.22
fu 0.17 ± 0.04 0.19 ± 0.01 0.19 ± 0.07