Table 1 Pharmacokinetic parameters of vincristine sulphate after intravenous administration of 0.15 mg/kg solution in normolipidemic (NL), intermediate hyperlipidemic (IHL), and extreme hyperlipidemic (HL) rats
From: The effect of increased lipoproteins levels on the disposition of vincristine in rat
NL | IHL | HL | |
|---|---|---|---|
Co (mg/L) | 1.03 ± 0.50 | 0.50 ± 0.29 | 0.99 ± 0.76 |
AUC0–∞ (mg.h/L) | 4.20 ± 3.23 | 2.25 ± 0.67 | 3.72 ± 1.38 |
λz (h-1) | 0.06 ± 0.03 | 0.03 ± 0.01 | 0.04 ± 0.03 |
t ½ (h) | 14.6 ± 7.62 | 30.3 ± 11.6 | 28.2 ± 18.3 |
CL/kg (L/h/kg) | 0.06 ± 0.04 | 0.07 ± 0.02 | 0.05 ± 0.02 |
Vβ/kg (L/kg) | 1.53 ± 1.80 | 2.88 ± 0.52 | 1.74 ± 1.15 |
Vc/kg (L/kg) | 0.17 ± 0.08 | 0.39 ± 0.21 | 0.27 ± 0.22 |
fu | 0.17 ± 0.04 | 0.19 ± 0.01 | 0.19 ± 0.07 |