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Table 1 Advantages and disadvantages of clinical DNL techniques

From: Clinical assessment of hepatic de novo lipogenesis in non-alcoholic fatty liver disease

DNL Technique Advantages Disadvantages
Stable label isotope Fluxed based assay
Selection of stable isotopes
Moderate sensitivity
Reproducible results
Cost of stable label substrates
Enrichment period (up to 7 days prior to experiment)
Requires specialized equipment for analysis
Fatty acid profiling Relatively inexpensive
Simple to execute
High sensitivity
High throughput
Requires specialized equipment for analysis
Indirect calorimetry Non-invasive (no blood sample required) Not hepatic specific