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Table 3 Interaction of MTRR A66G polymorphism with overweight/obesity on serum lipid levels

From: Gender-specific interactions of MTHFR C677T and MTRR A66G polymorphisms with overweight/obesity on serum lipid levels in a Chinese Han population

BMI

Genotype

n

TG (mmol/L)

Lg (TG)

TC (mmol/L)

HDL-C (mmol/L)

LDL-C (mmol/L)

Total

 <24

AA

511

0.73 (0.54–1.10)

−0.10 ± 0.24

4.84 ± 1.01

1.31 ± 0.36

2.68 ± 0.96

AG

309

0.72 (0.53–1.07)

−0.10 ± 0.27

4.84 ± 1.02

1.35 ± 0.34

2.64 ± 0.93

GG

65

0.77 (0.59–1.20)

−0.07 ± 0.25

4.82 ± 0.90

1.31 ± 0.36

2.62 ± 0.90

  ≥ 24

AA

774

1.24 (0.86–1.87)

0.11 ± 0.28a, b, c

5.07 ± 0.93a, b

1.14 ± 0.28a, b, c

2.84 ± 0.96b

AG

492

1.21 (0.84–1.69)

0.09 ± 0.25a, b, c

5.03 ± 0.98

1.14 ± 0.28a, b, c

2.81 ± 0.99

GG

88

1.21 (0.77–2.14)

0.11 ± 0.27a, b, c

5.22 ± 0.95

1.25 ± 0.33d, e

2.95 ± 1.02

  P* interaction

  

-

0.438

0.688

0.050

0.608

Female

 <24

AA

277

0.69 (0.49–0.94)

−0.15 ± 0.24

4.80 ± 0.97

1.37 ± 0.38

2.65 ± 0.97

AG

158

0.66 (0.48–0.90)

−0.15 ± 0.27

4.88 ± 0.93

1.39 ± 0.36

2.70 ± 0.91

GG

35

0.68 (0.52–0.89)

−0.14 ± 0.22

4.88 ± 1.00

1.39 ± 0.41

2.64 ± 0.90

  ≥ 24

AA

155

0.96 (0.65–1.41)

−0.00 ± 0.25a, b

5.01 ± 0.97

1.22 ± 0.31a, b

2.72 ± 0.90

AG

107

1.00 (0.70–1.46)

0.01 ± 0.25a, b

5.01 ± 1.07

1.19 ± 0.31a, b, c

2.84 ± 0.96

GG

18

0.96 (0.57–1.19)

−0.02 ± 0.27

5.31 ± 1.12

1.46 ± 0.50f

3.03 ± 1.01

  P* interaction

  

-

0.598

0.937

0.056

0.593

Male

 <24

AA

234

0.83 (0.63–1.24)

−0.05 ± 0.23

4.88 ± 1.06

1.23 ± 0.32

2.71 ± 0.95

AG

151

0.82 (0.57–1.25)

−0.06 ± 0.25

4.79 ± 1.11

1.29 ± 0.31

2.57 ± 0.95

GG

30

1.02 (0.63–1.47)

0.02 ± 0.26

4.75 ± 0.80

1.22 ± 0.28

2.60 ± 0.92

  ≥ 24

AA

619

1.30 (0.90–1.97)

0.14 ± 0.27a, b

5.09 ± 0.92b

1.12 ± 0.27a, b

2.87 ± 0.97b

AG

385

1.27 (0.87–1.78)

0.11 ± 0.25a, b

5.04 ± 0.95

1.13 ± 0.28a, b

2.81 ± 1.00

GG

70

1.32 (0.82–2.20)

0.14 ± 0.26a, b

5.20 ± 0.91

1.19 ± 0.25

2.93 ± 1.03

  P* interaction

  

-

0.430

0.606

0.109

0.649

  1. BMI body mass index, MTRR methionine synthase reductase
  2. *Adjusted for age
  3. a P < 0.05 in comparison with AA genotype of the BMI < 24 subgroup
  4. b P < 0.05 in comparison with AG genotype of the BMI < 24 subgroup
  5. c P < 0.05 in comparison with GG genotype of the BMI < 24 subgroup
  6. d P < 0.05 in comparison with AA genotype of the BMI ≥ 24 subgroup
  7. e P = 0.084 in comparison with AG genotype of the BMI ≥ 24 subgroup
  8. f P = 0.058 in comparison with AG genotype of the BMI ≥ 24 subgroup