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Table 1 Morphometric and metabolic profile of SHR, SHR-Dca +/− and SHR-Dca −/− male rats

From: Heterozygous connexin 50 mutation affects metabolic syndrome attributes in spontaneously hypertensive rat

Trait SHR SHR-Dca+/− SHR-Dca−/− p-value
Body weight (b.wt.), g 299 ± 6 299 ± 9 281 ± 8 0.16
Liver, g/100 g b.wt. 3.19 ± 0.02 3.29 ± 0.08 3.16 ± 0.09 0.41
Heart, g/100 g b.wt. 0.44 ± 0.01 0.45 ± 0.01 0.45 ± 0.01 0.99
Kidney, g/100 g b.wt. 0.77 ± 0.01 0.77 ± 0.01 0.77 ± 0.01 0.98
Adrenals, mg/100 g b.wt. 8.46 ± 0.04 8.50 ± 0.04 9.58 ± 0.07 0.21
EFP wt., g/100 g b.wt. 1.05 ± 0.03 1.14 ± 0.03 b 0.92 ± 0.05* 0.005
RFP wt., g/100 g b.wt. 0.91 ± 0.05 0.98 ± 0.05 0.79 ± 0.09 0.16
Glycerol (mg/dl) 2.97 ± 0.32 2.73 ± 0.23 3.12 ± 0.30 0.67
Adiponectin (μg/ml) 5.14 ± 0.56 5.58 ± 0.30 5.42 ± 0.24 0.72
C-peptide, pg/ml 615 ± 57 653 ± 39a 425 ± 42* 0.046
GIP, pg/ml 163 ± 25 247 ± 33*,a 122 ± 20 0.031
GLP1, pg/ml 102 ± 56 68 ± 41 71 ± 44 0.86
Glucagon, pg/ml 155 ± 50 365 ± 111 153 ± 35 0.10
Insulin, ng/ml 2.32 ± 0.49 3.04 ± 0.21b 1.11 ± 0.20* 0.025
PP, pg/ml 39.3 ± 3.9 45.1 ± 4.3 39.2 ± 3.5 0.52
PYY, pg/ml 79.3 ± 10.0 96.3 ± 15.6 76.6 ± 13.5 0.53
Leptin, ng/ml 6.38 ± 0.39 6.51 ± 0.35 6.41 ± 0.52 0.97
  1. Data are shown as mean ± SEM. The significance levels of one-way ANOVA for STRAIN as a major factor are shown in the last column; significant values are italicized. * p < 0.05 for pair-wise comparisons (post-hoc Tukey’s HSD test) between SHR-Dca−/− or SHR-Dca+/− strains vs. SHR. a p < 0.05 and b p < 0.01 for pair-wise comparisons between SHR-Dca−/− and SHR-Dca+/− strains. b.wt: body weight; EFP epididymal fat pad, RFP retroperitoneal fat pad, GIP gastric inhibitory polypeptide, GLP1 glucagon-like polypeptide-1, PP pancreatic polypeptide, PYY protein tyrosine tyrosine. * p < 0.05 vs. SHR. a p < 0.05 vs. SHR-Dca−/−. b p < 0.01 vs. SHR-Dca−/−