Heterozygous connexin 50 mutation affects metabolic syndrome attributes in spontaneously hypertensive rat

Table 1 Morphometric and metabolic profile of SHR, SHR-Dca +/− and SHR-Dca −/− male rats

Trait	SHR	SHR-Dca+/−	SHR-Dca−/−	p-value
Body weight (b.wt.), g	299 ± 6	299 ± 9	281 ± 8	0.16
Liver, g/100 g b.wt.	3.19 ± 0.02	3.29 ± 0.08	3.16 ± 0.09	0.41
Heart, g/100 g b.wt.	0.44 ± 0.01	0.45 ± 0.01	0.45 ± 0.01	0.99
Kidney, g/100 g b.wt.	0.77 ± 0.01	0.77 ± 0.01	0.77 ± 0.01	0.98
Adrenals, mg/100 g b.wt.	8.46 ± 0.04	8.50 ± 0.04	9.58 ± 0.07	0.21
EFP wt., g/100 g b.wt.	1.05 ± 0.03	1.14 ± 0.03 ^b	0.92 ± 0.05*	0.005
RFP wt., g/100 g b.wt.	0.91 ± 0.05	0.98 ± 0.05	0.79 ± 0.09	0.16
Glycerol (mg/dl)	2.97 ± 0.32	2.73 ± 0.23	3.12 ± 0.30	0.67
Adiponectin (μg/ml)	5.14 ± 0.56	5.58 ± 0.30	5.42 ± 0.24	0.72
C-peptide, pg/ml	615 ± 57	653 ± 39^a	425 ± 42*	0.046
GIP, pg/ml	163 ± 25	247 ± 33*^,a	122 ± 20	0.031
GLP1, pg/ml	102 ± 56	68 ± 41	71 ± 44	0.86
Glucagon, pg/ml	155 ± 50	365 ± 111	153 ± 35	0.10
Insulin, ng/ml	2.32 ± 0.49	3.04 ± 0.21^b	1.11 ± 0.20*	0.025
PP, pg/ml	39.3 ± 3.9	45.1 ± 4.3	39.2 ± 3.5	0.52
PYY, pg/ml	79.3 ± 10.0	96.3 ± 15.6	76.6 ± 13.5	0.53
Leptin, ng/ml	6.38 ± 0.39	6.51 ± 0.35	6.41 ± 0.52	0.97

Data are shown as mean ± SEM. The significance levels of one-way ANOVA for STRAIN as a major factor are shown in the last column; significant values are italicized. * p < 0.05 for pair-wise comparisons (post-hoc Tukey’s HSD test) between SHR-Dca−/− or SHR-Dca+/− strains vs. SHR. ^a p < 0.05 and ^b p < 0.01 for pair-wise comparisons between SHR-Dca−/− and SHR-Dca+/− strains. b.wt: body weight; EFP epididymal fat pad, RFP retroperitoneal fat pad, GIP gastric inhibitory polypeptide, GLP1 glucagon-like polypeptide-1, PP pancreatic polypeptide, PYY protein tyrosine tyrosine. * p < 0.05 vs. SHR. ^a p < 0.05 vs. SHR-Dca−/−. ^b p < 0.01 vs. SHR-Dca−/−

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