Positive association between serum apolipoprotein M levels and hepatitis B virus DNA load in HBeAg-negative chronic hepatitis B

Table 3 Association of clinical findings of chronic hepatitis B with HBV DNA levels

	HBV DNA < median*	HBV DNA > median*	p-value
Subjects, n	36	37
Demographics
Age, years	47 ± 12	42 ± 12	0.109
Sex, % male	84	86	0.364
Body mass index, kg/m²	22.2 ± 2.0	22.4 ± 2.4	0.487
Lipid profile
Triglycerides, mmol/L	1.68 ± 0.51	1.77 ± 0.52	0.817
Total cholesterol, mmol/L	3.51 ± 1.31	3.19 ± 1.34	0.308
HDL-C, mmol/L	0.76 ± 0.48	0.58 ± 0.44	0.099
LDL-C, mmol/L	2.07 ± 0.97	1.86 ± 0.82	0.326
Apolipoprotein A, g/L	0.74 ± 0.37	0.61 ± 0.41	0.177
Apolipoprotein B, g/L	0.93 ± 0.45	1.05 ± 0.43	0.241
Apolipoprotein M, mg/L	41.41 ± 21.84	63.38 ± 29.84	0.001
Lipoprotein(a), g/L	30.27 ± 2.64	14.32 ± 3.41	0.005
Liver biochemistry profile
Alanine aminotransferase, IU/L	45.3 ± 3.9	213.8 ± 3.4	<0.001
Aspartate transaminase, IU/L	54.6 ± 2.4	179.8 ± 2.6	<0.001

HBV DNA levels were categorized as higher or lower than the median log copies/mL (4.23 log copies/mL). Values for triglycerides, lipoprotein (a), alanine aminotransferase, and aspartate transaminase were converted into logarithmic form before analysis. p < 0.05 was considered statistically significant
HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, IU international units

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