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Fig. 3 | Lipids in Health and Disease

Fig. 3

From: Myeloperoxidase-oxidized high density lipoprotein impairs atherosclerotic plaque stability by inhibiting smooth muscle cell migration

Fig. 3

Oxidation of HDL inhibits SMC migration while HDL promotes SMC migration. a Primary aortic SMCs were cultured on 12-well plate until confluent, when an in vitro wound healing assay was performed. The native HDL and oxHDL were applied to SMCs at a concentration of 100 μg /ml for 48 h. Photographs of cells were taken 48 h after scratch. b In vitro transwell assay was performed to analyze SMC migration. The native and oxHDL were applied to SMCs at a concentration of 100 μg /ml for 12 h. The cells were stained and photographed. c The cells in wound healing assay were photographed 0 and 48 h after scratch, the relative area of SMC migration was compared. d Migrated cells in transwell assay were counted and compared (*p < 0.05, **p < 0.01 compared with non-treated group (NT), ##p < 0.01 compared with HDL group)

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Lipids in Health and Disease

ISSN: 1476-511X