Fig. 1
Time/dose response of schisandrin B (Sch B) treatment on serum triglyceride (TG) and total cholesterol (TC) levels. Mice were orally administered with Sch B (1 g/kg, suspended in olive oil). Control (untreated) animals received the vehicle (5 ml/kg) only. For the time course study, serum TG and TC levels were measured at 12, 24, 48, 72, 96, and 120 h after Sch B treatment or 24 h post-vehicle treatment (a and c). Preliminary studies indicated that vehicle-treated mice did not show any changes in serum lipids from 12 to 120 h post treatment. For the dose–response study, serum TG and TC were determined at 24 h in the Sch B-treated mice. Pharmacodynamic parameters (b and d) E max (maximal effect), K D (affinity), and pD 2 (an index of affinity) were estimated with the Scott’s plot method. Values given are the mean ± SEM, with n = 10. *P < 0.05, **P < 0.01 vs control, using a one-way ANOVA followed by Dunnett’s multiple comparisons test, Student’s t-test or post-hoc analysis