Fig. 5
Time/dose response of Sch B treatment on hepatic triglyceride (TG) and total cholesterol (TC) contents. Experimental details were described in Fig. 1. For the time course study, hepatic TG and TC contents were measured at 12, 24, 48, 72, 96, and 120 h after Sch B treatment (a and c). For the dose–response study, mice were intragastrically treated with Sch B (0.25–2 g/kg). Twenty-four h and forty-eight h later, the pharmacodynamic parameters E max, K D, and pD 2 were determined (b, d and e). Values given are the mean ± SEM, with n = 10. *P < 0.05, **P < 0.01 vs Control, using a one-way ANOVA followed by Dunnett’s multiple comparisons test, Student’s t-test or post-hoc analysis