Table 1 Mean and SEM values for the primary parameters total cholesterol, LDL assessed by three different methods, HDL assessed by four different methods, non-HDL-c (calculated), and triglycerides assessed by two different methods in serum from the NHPs at baseline, during and after treatment with the omega-3 rich phospholipid preparation. Dose levels of the phospholipids, EPA, DHA and choline are given at the end of the table

Total cholesterol (mg/dL)

Control

Mean

139

138

139

141

143

144

138

142

156

147

142

145

149

153

169

164

172

SEM

25.9

23.9

26.5

24.1

22.0

31.9

18.3

21.7

20.8

22.6

20.2

18.6

23.8

22.5

30.8

32.7

34.0

Treated

Mean

173

172

192

176

176

177

147

148

176

137

140

143

140

155

178

182

196

SEM

41.2

41.2

51.3

37.0

43.6

43.6

19.9

21.2

34.9

22.6

30.8

26.9

21.1

33.5

50.6

53.1

57.7

0

0

9

1

−2

0

−12

−15

−12

−27

−23

−24

−26

−21

−24

−18

−15

LDL-c by Selective-chemically clearing method (mg/dL)

Control

Mean

57.7

57.5

54.5

54.1

53.1

54.8

55.9

50.9

60.3

61.6

65.6

59.0

65.9

67.0

71.9

71.0

66.6

SEM

11.7

6.07

7.15

7.16

4.47

11.98

2.76

4.70

3.80

4.81

6.40

2.07

4.71

4.60

6.96

6.13

7.61

Treated

Mean

85.2

91.6

95.8

87.8

87.4

91.9

64.1

61.9

81.1

61.9

48.1

66.3

64.1

75.8

87.7

94.5

98.7

SEM

35.8

38.7

44.4

36.3

36.1

37.3

18.2

17.9

30.1

19.4

5.2

25.5

24.2

27.9

38.6

39.6

38.8

0

4

12

7

7

13

−20

−12

−11

−35

−47

−29

−43

−29

−31

−20

−1

LDL particles by NMR (nmol/L)

Control

Mean

587

-

621

-

664

-

727

-

758

-

728

-

633

876

724

762

760

SEM

175

-

184

-

258

-

258

-

223

-

219

-

130

239

184

220

221

Treated

Mean

1085

-

1177

-

1229

-

828

-

1171

-

424

-

627

1000

1058

985

875

SEM

612

-

614

-

633

-

325

-

455

-

247

-

300

423

444

423

259

0

9

14

−21

5

−51

−28

−14

23

−1

4

ApoB100 by immune turbidimetry (g/L)

Control

Mean

0.37

0.36

0.36

0.39

0.37

0.38

0.38

0.41

0.46

0.47

0.52

0.54

0.55

0.58

0.63

0.61

0.60

SEM

0.06

0.05

0.04

0.04

0.05

0.10

0.06

0.08

0.08

0.09

0.09

0.09

0.11

0.11

0.15

0.17

0.16

Treated

Mean

0.52

0.50

0.57

0.56

0.64

0.55

0.43

0.45

0.58

0.48

0.57

0.59

0.55

0.62

0.72

0.74

0.78

SEM

0.19

0.19

0.22

0.18

0.27

0.17

0.12

0.12

0.17

0.13

0.18

0.20

0.16

0.20

0.28

0.30

0.31

0

−8

6

0

12

7

−19

−22

−14

−31

−30

−36

−40

−36

−31

−26

−13

HDL-c by Polymer-Detergent method (mg/dL)

Control

Mean

83.8

86.2

86.1

88.7

90.1

94.6

88.4

96.7

106

99.9

93.5

100

102

106

122

119

121

SEM

12.2

13.6

12.3

11.6

16.0

27.1

14.0

21.5

22.1

25.9

17.6

21.9

26.6

23.5

35.3

37.7

38.2

Treated

Mean

124

118

138

124

127

123

93.3

97.4

122

86.9

100

96.0

88.3

105

130

136

146

SEM

46.2

45.5

53.5

38.7

45.5

43.9

20.8

22.1

33.7

23.1

41.5

31.5

23.8

35.6

53.6

56.9

61.3

0

20

17

17

10

27

23

21

22

18

−13

13

23

19

15

13

11

HDL concentration (calculated) by NMR (mg/dL)

Control

Mean

67.3

-

66.3

-

65.3

-

60.3

-

56.3

-

58.3

-

56.3

56.3

58.7

58.7

63.3

SEM

13.3

-

18.0

-

17.7

-

15.9

-

11.3

-

10.3

-

13.6

11.6

14.3

14.7

14.0

Treated

Mean

62.0

-

66.0

-

58.3

-

69.7

-

62.0

-

56.0

-

72.0

64.7

61.7

62.0

61.0

SEM

11.5

-

7.81

-

8.25

-

8.17

-

5.03

-

18.1

-

9.64

5.67

7.80

9.64

8.62

0

14

1

29

20

8

36

25

15

15

7

HDL particles by NMR (μmol/L)

Control

Mean

36.7

-

34.9

-

34.8

-

33.5

-

32.7

-

34.5

-

35.3

34.2

36.9

37.4

39.7

SEM

6.46

-

5.66

-

5.49

-

6.00

-

4.85

-

4.53

-

4.61

4.75

6.03

5.32

4.75

Treated

Mean

35.0

-

38.3

-

36.7

-

35.1

-

35.8

-

40.3

-

39.0

36.7

39.6

38.2

38.8

SEM

1.31

-

1.19

-

1.33

-

2.08

-

2.21

-

4.33

-

2.27

1.41

1.79

1.20

1.19

0

14

10

9

12

16

14

11

12

6

1

ApoA1 by immune turbidimetry (g/L)

Control

Mean

0.98

0.93

0.96

0.93

0.97

0.88

0.94

0.95

0.99

0.94

0.94

0.90

0.90

0.93

0.90

1.24

1.34

SEM

0.08

0.08

0.09

0.06

0.08

0.08

0.08

0.08

0.07

0.07

0.06

0.05

0.06

0.07

0.06

0.24

0.25

Treated

Mean

0.98

0.97

1.02

0.96

1.08

0.94

0.99

0.98

1.02

0.95

0.82

0.90

1.01

0.98

0.93

1.27

1.35

SEM

0.05

0.03

0.04

0.02

0.10

0.03

0.04

0.03

0.05

0.02

0.13

0.04

0.05

0.03

0.03

0.12

0.14

0

4

7

3

12

7

5

4

3

2

−2

0

11

5

3

4

1

Non-HDL-c (calculated) (mg/dL)

Control

Mean

83.8

86.2

86.1

88.7

90.1

94.6

88.4

96.7

106.2

99.9

93.5

100

102

106

122

119

121

SEM

12.2

13.6

12.3

11.6

16.0

27.1

14.0

21.5

22.1

25.9

17.6

21.9

26.6

23.5

35.3

37.7

38.2

Treated

Mean

124

118

138

124

127

123

93.3

97.4

122

86.9

100

96.0

88.3

105

130

136

146

SEM

46.2

45.5

53.5

38.7

45.5

43.9

20.8

22.1

33.7

23.1

41.5

31.5

23.8

35.6

53.6

56.9

61.3

0

−8

7

−2

−5

−9

−23

−28

−23

−44

−33

−41

−45

−38

−43

−34

−27

Triglycerides by enzymic method (GK-PK-LDH) (mg/dL)

Control

Mean

99.8

133

123

143

174

174

141

194

213

200

164

210

208

210

239

267

312

SEM

57.3

95.4

85.4

104

127

137

88.3

143

156

149

111

153

168

150

192

217

262

Treated

Mean

211

138

225

182

239

129

123

125

188

107

192

123

93

165

231

262

267

SEM

98.5

71.9

102

72.5

103

51.6

40.3

39.7

66.3

42.2

134

59.0

24.7

72.2

126

146

156

0

−46

−5

−17

−20

−53

−49

−61

−40

−90

−58

−92

−74

−48

−28

−46

−69

Triglycerides (calculated) by NMR (mg/dL)

Control

Mean

79.0

-

101

-

151

-

119

-

174

-

141

-

172

178

221

211

256

SEM

30.0

-

45.2

-

93.0

-

65.8

-

116

-

88.7

-

120

119

166

157

200

Treated

Mean

166

-

158

-

184

-

87

-

131

-

105

-

65.3

127

190

196

220

SEM

63.6

-

56.5

-

69.4

-

20.6

-

41.0

-

64.2

-

10.0

52.2

103

101

129

0

−32

−80

−98

−142

−115

−178

−149

−166

−149

−192