Table 5 Vital data and results from the screening of the animals included in the study. The normal range values refer to values measured in normal, non-diabetic cynomolgus monkeys housed at the laboratory where this study was conducted
Group | Animal ID | Sex | Age (years) | Bodyweight (kg) | Screening parameters | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
TC | LDL | HDL | TG | Hb1Ac | Glucose | Insulin | |||||
(mg/dL) | (mg/dL) | (mg/dL) | (mg/dL) | (%) | (mg/dL) | (mIU/L) | |||||
Control | Control no. 1 | M | 14 | 9.22 | 140 | 57.0 | 57.0 | 162 | 13.8 | 261 | 9.70 |
Control no. 2 | M | 15 | 10.0 | 103 | 48.0 | 38.0 | 55.0 | 10.2 | 234 | 22.4 | |
Control no. 3 | F | 13 | 4.32 | 191 | 76.0 | 80.0 | 89.0 | 4.6 | 67 | 36.7 | |
Treated | Treated no. 1 | M | 14 | 8.30 | 188 | 74.0 | 60.0 | 269 | 17.5 | 157 | 200 |
Treated no. 2 | F | 21 | 7.34 | 256 | 162 | 40.0 | 400 | 10.1 | 224 | 56.1 | |
Treated no. 3 | M | 20 | 10.8 | 128 | 49.0 | 61.0 | 50.0 | 5.90 | 109 | 51.8 | |
Normal range | 97 ± 4 | 35 ± 3 | 30–55 | 14–88 | ≤5 | 40–75 | 20–50 | ||||