SLC12A3 variants modulate LDL cholesterol levels in the Mongolian population

Table 3 Effects of haplotypes constructed by three positive SNPs on LDL-c levels

Haplotypes ^a	Frequency (%)	AddVal	95%Lo	95%Hi	Chisq	p ^b	Global p ^b
	rs5803(T/C)-rs2010501(C/T)
T-T	22.43	−0.044	−0.042	0.335	4.927	0.026	2.23e-4
C-C	18.65	−0.448	−0.852	−0.043	14.03	1.80e-4
C-T	55.25	−0.105	−0.453	0.243	1.002	0.317
	rs2010501(C/T)-rs711746(G/A)
C-G	21.81	-	-	-	10.56	1.15e-3	7.68e-4
T-G	16.16	0.145	−0.065	0.355	0.734	0.391
T-A	61.65	0.291	0.128	0.453	12.56	3.95e-4
	rs5803(T/C)-rs2010501(C/T)-rs711746(G/A)
T-T-A	21.90	−0.050	−0.502	0.402	4.521	0.033	5.76e-4
C-C-G	18.61	−0.426	−0.898	0.045	12.43	4.22e-4
C-T-G	15.40	−0.224	−0.627	0.180	0.967	0.325
C-T-A	39.52	−0.062	−0.509	0.386	3.035	0.812

Abbreviation: Fre. is the frequencies of risk haplotypes, AddVal the estimated additive genetic value relative to the reference haplotype, 95% Lo 95% lower confidence limit for the additive value, 95% Hi 95% upper confidence limit for the additive value
^aThe haplotypes frequencies < 0.05 were excluded in global p-value calculation
^bBold type denotes p < 0.05

ISSN: 1476-511X