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Table 3 Effects of haplotypes constructed by three positive SNPs on LDL-c levels

From: SLC12A3 variants modulate LDL cholesterol levels in the Mongolian population

Haplotypes a Frequency (%) AddVal 95%Lo 95%Hi Chisq p b Global p b
  rs5803(T/C)-rs2010501(C/T)   
T-T 22.43 −0.044 −0.042 0.335 4.927 0.026 2.23e-4
C-C 18.65 −0.448 −0.852 −0.043 14.03 1.80e-4
C-T 55.25 −0.105 −0.453 0.243 1.002 0.317
  rs2010501(C/T)-rs711746(G/A)   
C-G 21.81 - - - 10.56 1.15e-3 7.68e-4
T-G 16.16 0.145 −0.065 0.355 0.734 0.391
T-A 61.65 0.291 0.128 0.453 12.56 3.95e-4
  rs5803(T/C)-rs2010501(C/T)-rs711746(G/A)   
T-T-A 21.90 −0.050 −0.502 0.402 4.521 0.033 5.76e-4
C-C-G 18.61 −0.426 −0.898 0.045 12.43 4.22e-4
C-T-G 15.40 −0.224 −0.627 0.180 0.967 0.325
C-T-A 39.52 −0.062 −0.509 0.386 3.035 0.812
  1. Abbreviation: Fre. is the frequencies of risk haplotypes, AddVal the estimated additive genetic value relative to the reference haplotype, 95% Lo 95% lower confidence limit for the additive value, 95% Hi 95% upper confidence limit for the additive value
  2. aThe haplotypes frequencies < 0.05 were excluded in global p-value calculation
  3. bBold type denotes p < 0.05