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Fig. 4 | Lipids in Health and Disease

Fig. 4

From: RETRACTED ARTICLE: Progranulin causes adipose insulin resistance via increased autophagy resulting from activated oxidative stress and endoplasmic reticulum stress

Fig. 4

The administration of the ER stress inhibitor 4-PBA reversed the negative effect of progranulin in vivo. a Protein expression of iNOS in adipose tissue. b The relative protein quantity of iNOS in adipose tissue. c Nitrite concentrations in adipose tissue. d Protein expression of CHOP and GRP78, and the phosphorylation of PERK in adipose tissue. e The relative protein quantity of CHOP, GRP78 and p-PERK in adipose tissue. f Protein expression of Atg7, p62 and LC3 in adipose tissue. g The relative protein quantity of Atg7, p62 and LC3 in adipose tissue. h IRS-1 tyrosine phosphorylation in adipose tissue. i The relative protein quantity of IRS-1 tyrosine phosphorylation in adipose tissue. j GTT. k ITT. The relative quantity of proteins was analyzed using Quantity One software. A representative blot is shown and the data was expressed as mean ± SEM in each bar graph. *P < 0.05 (PGRN vs Control); # P < 0.05 (PGRN + 4-PBA vs PGRN)

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Lipids in Health and Disease

ISSN: 1476-511X