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Fig. 5 | Lipids in Health and Disease

Fig. 5

From: Dietary intervention, but not losartan, completely reverses non-alcoholic steatohepatitis in obese and insulin resistant mice

Fig. 5

Effect of dietary intervention (Return to NCD) and losartan (HF-HSD-LOS) on mitochondrial parameters. a mRNA levels of genes involved in fatty acid β-oxidation: Peroxisome proliferator activated receptor α (PPAR-α), carnitine palmitoyltransferase 1A (CPT1A) and medium chain acyl-Coenzyme A dehydrogenase (MCAD). b mRNA levels of genes involved in regulation of mitochondrial function (Peroxisome proliferator-activated receptor gamma coactivator 1-α (PGC1-α), Sirtuin1 (SIRT1), uncoupling protein 2 (UCP2) and tumor necrosis factor-α (TNF-α)). c ATP content. d HNE concentration as marker of oxidative stress. Asterisks indicate significant difference versus HF-HSD mice. N = 9 per group for all assays. Data are presented as mean. Error bars are SEM

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Lipids in Health and Disease

ISSN: 1476-511X