Effect of the R92H and A379V genotypes of platelet-activating factor acetylhydrolase on its enzyme activity, oxidative stress and metabolic profile in Chinese women with polycystic ovary syndrome

Table 5 Oxidative stress parameters and PAF-AH activities according to PAF-AH A379V genotype in PCOS patients and control women

	Controls		PCOS
	AA (n = 371)	AV + VV (n = 121 + 9)	AA (n = 432)	AV + VV (n = 125 + 8)
Age (yr)	27.85 ± 4.33	28.15 ± 3.80	24.79 ± 3.95	24.39 ± 3.70
BMI (kg/m²)	20.98 ± 3.00	21.33 ± 2.53	23.21 ± 4.41	22.66 ± 3.62
Oxidative stress parameters
TOS (nmol H₂O₂ Equiv./mL)	11.06 ± 5.13	11.51 ± 5.81	14.95 ± 11.25	15.00 ± 9.43
T-AOC (U/ml/min)	14.58 ± 2.62	14.39 ± 2.86	15.82 ± 3.12	15.86 ± 2.92
OSI	0.78 ± 0.39	0.83 ± 0.44	1.00 ± 0.84	0.99 ± 0.65
MDA (nmol/ml)	3.64 ± 1.05	3.69 ± 1.15	4.38 ± 1.31	4.27 ± 1.31
PAF-AH activities and frequencies of PAF-AH G449T genotype^a
Plasma PAF-AH (nmol/min/ml)	48.22 ± 10.85	48.68 ± 10.79	47.37 ± 13.78	47.70 ± 9.09
H-PAF-AH (nmol/min/ml)	5.17 ± 1.57	4.96 ± 1.21	4.67 ± 2.03	4.66 ± 1.40
ApoB-PAF-AH (nmol/min/ml)	43.04 ± 9.92	43.72 ± 10.12	42.70 ± 12.63	43.04 ± 8.53
ApoB-PAF-AH/H-PAF-AH	8.79 ± 2.52	9.13 ± 2.34	9.97 ± 3.07	10.31 ± 6.10
PAF-AH G449T, n (%)
GG	185 (92.0%)	70 (94.6%)	190 (85.2%)	53 (91.4%)
GT + TT	16 + 0 (8.0%)	4 + 0 (5.4%)	29 + 4 (14.8%)	5 + 0 (8.6%)

Values are presented as the mean ± SD
TOS total oxidant status, T-AOC total antioxidant capacity, OSI oxidative stress index, PAF-AH platelet activating factor acetylhydrolase, H-PAF-AH HDL-associated PAF-AH, ApoB-PAF-AH apolipoprotein B-containing lipoprotein-associated PAF-AH
Comparisons of oxidative stress parameters and PAF-AH activities were corrected for differences in age and BMI between the two groups
^aControls: AA (n = 201), AV + VV (n = 70 + 4); PCOS: AA (n = 223), AV + VV (n = 55 + 3)

ISSN: 1476-511X