Fig. 4
Model of dyslipidemic, hemolysis and endothelial dysfunction, vaso-occlusion/viscosity sub-phenotypes associated with laboratory data in SCA. Legend: 
(severe), 
(mildest), 
(severe), 
(mildest), 
(severe), 
(mildest). T-Chol, HDL-C and LDL-C levels exhibit an association, suggesting a new dyslipidemic sub-phenotype. Lactate dehydrogenase (LDH) and indirect bilirubin are important biomarkers of hemolytic and endothelial dysfunction sub-phenotypes. Hematocrit (Ht), red blood cell (RBC) and MCV are associated with –α3.7Kb-thalassemia, reflecting the vaso-occlusive/viscosity sub-phenotype. However, we observed that reticulocyte count is associated with hemolysis and vaso-occlusion. HbF, NO metabolites and monocyte count show influence among all the proposed sub-phenotypes. The laboratory parameters described exhibit peculiar phenotypic diversity that was difficult for separating the pathophysiological mechanism of SCA