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Table 2 Association of laboratory data between SCA patients in the presence or absence of -α3.7Kb-thalassemia

From: Association of classical markers and establishment of the dyslipidemic sub-phenotype of sickle cell anemia

 

Presence of -α3.7Kb -thalassemia (N = 14)

Absence of -α3.7Kb -thalassemia (N = 85)

P1

 

Median (25th -75th)

Median (25th -75th)

p-value

Hemolysis

 RBC, x1012/L

2.9 (2.5–3.3)

2.5 (2.2–2.7)

0.012

 Hemoglobin, g/dL

8.2 (7.3–8.8)

7.6 (7.1–8.3)

0.814*

 Hematocrit, %

23.8 (21.4–25.5)

21.7 (19.9–24.1)

0.839*

 MCV, fL

80.3 (76.3–83.0)

88.0 (83.6–93.2)

0.001

 MCH, fl

27.7 (25.7–29.0)

30.8 (28.8–32.7)

0.001

 Total bilirubin, mg/dL

1.8 (1.2–2.7)

2.8 (1.7–3.9)

0.026

 Direct bilirubin, mg/dL

0.4 (0.2–0.5)

0.5 (0.3–0.6)

0.180

 Indirect bilirubin, mg/dL

1.3 (0.9–2.2)

2.3 (1.3–3.4)

0.026

 LDH, U/L

958.0 (852.2–1845.7)

1120.0 (762.5–1693.0)

0.848*

 Reticulocyte count

4.6 (3.7–8.6)

5.8 (4.3–8.1)

0.736*

Hemoglobin profile

 Fetal hemoglobin, %

9.4 (3.4–13.9)

9.3 (5.2–14.4)

0.651

NO metabolites

 NOm, μM

33.9 (20.7–44.4)

35.7 (28.8–48.0)

0.400

Leukocytes

 WBC, x 109/L

12.3 (7.6–14.8)

14.0 (11.2–16.1)

0.161

 Neutrophil, x 109/L

5124.0 (3830.2–7061.7)

5796.0 (4208.5–7225.0)

0.550

 Eosinophil, x 109/L

582.5 (232.5–1936.5)

800.0 (303.50–1785.5)

0.676*

 Lymphocyte, x 109/L

3711.0 (2695.5–6960.7)

5688.0 (4533.0–7269.0)

0.036

 Monocyte, x 109/L

202.0 (124.5–432.7)

380.0 (252.0–702.0)

0.120*

Platelets

 Platelet, x103/mL

335.5 (239.2–443.0)

450.0 (382.0–559.0)

0.003

Lipid profile

 Total Cholesterol, mg/dL

118.5 (106.7–142.2)

123.0 (97.5–148.0)

0.810

 HDL-C, mg/dL

30.0 (24.7–38.0)

32.0 (27.0–37.5)

0.376

 LDL-C, mg/dL

68.0 (56.7–99.5)

67.0 (41.0–87.0)

0.396

 VLDL-C, mg/dL

22.5 (18.0–28.7)

22.0 (16.5–32.0)

0.936

 Triglycerides, mg/dL

111.0 (89.5–142.5)

110.0 (82.5–158.5)

0.928

  1. RBC red blood cells, MCV mean cell volume, MCH mean corpuscular hemoglobin, LDH lactate dehydrogenase, NOm nitric oxide metabolites, WBC white blood cell, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, VLDL-C very low-density lipoprotein cholesterol. Bold values indicate significance at p <0.05; p-value obtained using Mann- Whitney. *p-value obtained using t-test. P1 = presence of -α3.7Kb-thalassemia X absence of -α3.7Kb-thalassemia