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Table 2 Detection of Cyclin D1、p53、P16、P27、P21 and Rb mRNA expression by Quantitative Real Time PCR

From: E167K polymorphism of TM6SF2 gene affects cell cycle of hepatocellular carcinoma cell HEPA 1-6

groups Quantitative Real Time PCR
Cyclin D1 p53 Rb P27 P21 P16
variant type group 2.03 ± 0.01 1.88 ± 0.05 1.29 ± 0.06 0.56 ± 0.02 0.78 ± 0.06 1.00 ± 0.04
wild type group 1.00 ± 0.00 1.48 ± 0.09 1.18 ± 0.01 0.82 ± 0.05 0.77 ± 0.02 1.01 ± 0.06
the control group 1.04 ± 0.06 1.37 ± 0.03 1.15 ± 0.03 0.85 ± 0.05 0.78 ± 0.04 1.00 ± 0.06
t1 178.532 6.729 3.132 8.363 0.158 0.240
P1 <0.001 0.0016 0.041 <0.001 >0.05 >0.05
t2 28.190 15.152 3.615 9.328 0 0
P2 <0.001 <0.001 0.014 <0.001 >0.05 >0.05
t3 1.156 2.008 1.643 0.735 0.387 0.204
P3 >0.05 >0.05 >0.05 >0.05 >0.05 >0.05
  1. t1:between variant type group and wild type group; t2:between variant type group and the control group; t3:between wild type group and the control group;