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Fig. 4 | Lipids in Health and Disease

Fig. 4

From: The omega-3 polyunsaturated fatty acid docosahexaenoic acid inhibits proliferation and progression of non-small cell lung cancer cells through the reactive oxygen species-mediated inactivation of the PI3K /Akt pathway

Fig. 4

DHA increased the generation of ROS and inhibited the phosphorylation of Akt. The generation of ROS decreased with 50 μM and 75 μM, following a dose- dependent manner (Fig. 4 a). In terms of antioxidant enzymes, the expression of catalase significantly decreased (Fig. 4 b). DHA decreased the expression of PI3K slightly and markedly reduced the level of Akt phosphorylation (Fig. 4 c)

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Lipids in Health and Disease

ISSN: 1476-511X