Decreased circulating dihomo-gamma-linolenic acid levels are associated with total mortality in patients with acute cardiovascular disease and acute decompensated heart failure

Table 2 Univariate and multivariate Cox regression analyses for all-cause death

	Univariate			Multivariate (AA)			Multivariate (DGLA)			Multivariate (DGLA/AA)
	HR	95% CI	p	HR	95% CI	p	HR	95% CI	p	HR	95% CI	p
Age, 1 year increase	1.04	1.01–1.07	<0.01	1.02	0.98–1.06	NS	1.01	0.97–1.05	NS	1.00	0.97–1.04	NS
Male	1.45	0.73–3.02	NS	1.25	0.61–2.71	NS	1.41	0.67–3.12	NS	1.43	0.68–3.14	NS
Body mass index, 1 kg/m² increase	0.90	0.83–0.97	<0.01	0.95	0.87–1.04	NS	0.97	0.88–1.06	NS	0.95	0.87–1.04	NS
Diabetes mellitus	1.24	0.63–2.44	NS	1.29	0.56–3.05	NS	0.96	0.40–2.35	NS	1.11	0.45–2.70	NS
Dyslipidemia	0.38	0.19–0.75	<0.01	0.37	0.15–0.89	0.03	0.47	0.20–1.10	NS	0.37	0.16–0.85	0.02
Hypertension	0.88	0.44–1.83	NS	0.31	0.13–0.73	0.01	0.32	0.13–0.76	0.01	0.34	0.14–0.80	0.01
eGFR, 1 mL/min/1.73m² increase	0.96	0.94–0.98	<0.01	0.94	0.91–0.97	<0.01	0.94	0.91–0.97	<0.01	0.94	0.91–0.96	<0.01
Atrial fibrillation	1.05	0.53–2.07	NS	1.22	0.51–2.80	NS	1.07	0.45–2.43	NS	1.25	0.54–2.80	NS
Ejection fraction, 1% increase	1.00	0.97–1.02	NS	0.98	0.96–1.01	NS	0.99	0.97–1.01	NS	0.99	0.97–1.01	NS
AA, 1 μg/mL increase	0.99	0.98–1.00	0.01	1.00	0.99–1.01	NS		-			-
DGLA, 1 μg/mL increase	0.92	0.88–0.96	<0.01		-		0.94	0.89–0.99	0.03		-
DGLA/AA, 0.01 increase	0.92	0.85–0.98	0.01		-			-		0.87	0.78–0.98	0.02

eGFR Estimated glomerular filtration rate, AA Arachidonic acid, DGLA Dihomo-gamma-linolenic acid

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