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Table 1 Clinical characteristics of overweight and obese children and adolescents stratified by ApoA5 genotype

From: The Arg282Ser missense mutation in APOA5 gene determines a reduction of triglyceride and LDL-cholesterol in children, together with low serum levels of apolipoprotein A-V

 

Genotypes

P

 

GG

n. = 901

GT

n. = 24

 

Females/Males*

477/424

10/14

0.380

Age (years)

10.4 ± 3.2

9.9 ± 3.2

0.500

Weight (Kg)

57 ± 19.8

55 ± 18.5

0.602

BMI (Kg/m2)

27.4 ± 4.2

29.1 ± 9.3

0.216

SDS-WEIGHT

1.5 ± 0.9

1.5 ± 0.8

0.855

SDS-BMI

2.8 ± 1.2

3.6 ± 2.9

0.103

SBP (mm/Hg)

106 ± 14.8

105 ± 14.6

0.811

DBP (mm/Hg)

61.7 ± 8.8

63 ± 8.7

0.515

TC (mg/dl)

167.8 ± 32.3

149.7 ± 25.3

0.005

TG (mg/dl)

63.7 ± 39.5

48.2 ± 31.6

0.001

HDL-C (mg/dl)

51.5 ± 12.2

51.2 ± 11.1

0.996

LDL-C (mg/dl)

103.4 ± 28.2

88.6 ± 22.6

0.016

AST (U/L)

24.4 ± 10.7

25.6 ± 5.9

0.591

ALT (U/L)

23 ± 12.5

22.6 ± 7.8

0.873

BG 0′ (mg/dl)

89 ± 7.6

88.2 ± 6.3

0.656

BG 120′ (mg/dl)

105.5 ± 20.2

113.2 ± 17

0.055

Ins 0′ (μUI/ml)

14.7 ± 9.1

17.9 ± 12.4

0.376

Ins 120′ (μUI/ml)

61.4 ± 51

90.3 ± 73.5

0.087

HOMA-IR (U)

3.3 ± 2.1

4 ± 2.8

0.421

HOMA-B

218.3 ± 183

257.3 ± 177.6

0.314

  1. Values are expressed as means ± standard deviations
  2. Abbreviations: BMI body mass index, SDS Standard Deviation Score, SBP systolic blood pressure, DBP diastolic blood pressure, TC total cholesterol, TG plasma triglycerides, HDL-C high density lipoprotein-cholesterol, LDL-C low density lipoprotein cholesterol, AST aspartate aminotransferase, ALT, alanine aminotransferase, BG blood glucose, Ins insulin, HOMA-IR homeostatic model assessment of insulin resistance, HOMA-B homeostatic model assessment for beta-cell function U, Unit
  3. *P value was calculated by χ2. P values <0.05 are considered significant
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Lipids in Health and Disease

ISSN: 1476-511X