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Table 2 Association studies of individual rare alleles with NAFLD in Japanese individuals

From: Identification of deleterious rare variants in MTTP, PNPLA3, and TM6SF2 in Japanese males and association studies with NAFLD

Gene

dbSNP ID

Position

Logistic regression analysis

HWE

   

OR

(95% CI)

P

MAF

P

MTTP

rs756998920

Val42Ile

0.03

0.002–0.57

0.019

0.0033

0.855

MTTP

rs61750974

Val168Ile

1.28

0.63–2.58

0.493

0.0120

0.396

MTTP

rs760898561

Pro514Arg

1.52

0.26–8.73

0.641

0.0018

0.920

MTTP

rs771890416

Ser861Asn

0.74

0.07–7.38

0.798

0.0013

0.942

PNPLA3

rs143392071

Tyr220Cys

3.52

1.38–8.95

0.008

0.0056

0.755

PNPLA3

rs148469440

c.697-5C > A

2.15

0.8–5.47

0.127

0.0047

0.405

PNPLA3

rs147289545

Arg447Gln

0.63

0.16–2.4

0.497

0.0032

0.862

TM6SF2

rs142056540

Arg138Trp

0.42

0.05–3.65

0.432

0.0010

0.956

PNPLA3

rs738409

Ile148Met

1.66

1.41–1.96

1.44E-09

0.4667

0.073

TM6SF2

rs58542926

Glu167Lys

1.8

1.36–2.38

3.39E-05

0.0799

0.858

  1. Association of the individual SNP with NAFLD was assessed by Logistic regression analysis, which used age, sex, visceral fat depot, HbA1c, rs738409 and rs58542926 as covariates. Odds ratio (OR), 95% confidence interval (95%CI) and P value are shown. Minor allele frequency (MAF) and P value of Hardy-Weinberg equilibrium (HWE) are also exibited
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Lipids in Health and Disease

ISSN: 1476-511X