Feces and liver tissue metabonomics studies on the regulatory effect of aspirin eugenol eater in hyperlipidemic rats

Table 3 Potential biomarkers in feces associated with AEE treatment based on UPLC-Q-TOF/MS analysis in hyperlipidemic rat

NO.	RT	VIP	m/z	Formula	Metabolite	Trend
NO.	RT	VIP	m/z	Formula	Metabolite	M/C	AEE/M
1	6.8	6.04	391.2835	C₂₄H₃₈O₄	Nutriacholic acid	↑	↓
2	6.92	2.82	318.2996	C₁₈H₃₉NO₃	Phytosphingosine	↑	↑^*
3	7.53	4.67	300.2892	C₁₈H₃₇NO₂	Sphingosine	↑^*	↑
4	10.19	4.80	281.2468	C₁₈H₃₂O₂	Linoleic acid	↓^**	↑
5	13.25	3.27	428.3733	C₂₅H₄₉NO₄	Stearoylcarnitine	↑^**	↑
6	1.74	1.71	132.1011	C₆H₁₃NO₂	Leucine	↓^*	↓
7	3.55	1.77	161.1061	C₁₀H₁₂N₂	Tryptamine	↑	↑
8	7.54	2.20	282.2788	C₁₈H₃₅NO	Oleamide	↑^*	↑
9	0.67	1.51	145.1211	C₈H₁₆O₂	Caprylic acid	↓^**	↑
10	6.76	1.43	298.2731	C₁₈H₃₅NO₂	POEA	↑	↑
11	11.15	1.63	279.2312	C₁₆H₃₂O₂	Palmitic acid	↓^**	↑
12	16.55	1.52	328.3206	C₂₀H₄₁NO₂	Stearoylethanolamide	↑	↑
13	12.03	1.17	357.2785	C₂₄H₃₆O₂	THA	↑^**	↓^*
14	3.73	1.45	206.0449	C₁₀H₉NO₄	4-(2-A)-2,4-DA	↑^*	↑
15	4.36	1.74	165.0550	C₉H₁₀O₃	Phenyllactic acid	↓^**	↑^*
16	5.41	2.25	297.1122	C₁₈H₁₈O₄	Enterolactone	↓^**	↓
17	11.5	4.69	299.2580	C₁₈H₃₆O₃	13-HA	↓^**	↑
18	13.23	1.51	277.2163	C₁₈H₃₀O₂	Alpha-Linolenic acid	↓^**	↑
19	16.43	2.75	281.2475	C₁₈H₃₄O₂	Oleic acid	↓^**	↓
20	4.04	1.23	229.1435	C₁₂H₂₂O₄	Dodecanedioic acid	↓^**	↓
21	7.68	1.05	389.2685	C₂₄H₃₈O₄	12-Ketodeoxycholic acid	↓	↓
22	13.87	1.24	327.232	C₂₂H₃₂O₂	DHA	↓^**	↑

M/C: model versus control; AEE/M: AEE versus model; ^* P < 0.05, ^** P < 0.01. POEA: Palmitoleoyl ethanolamide; THA: Tetracosahexaenoic acid; 4-(2-A)-2,4-DA: 4-(2-Aminophenyl)-2,4-dioxobutanoic acid; DHA: Docosahexaenoic acid; 13-HA: 13-hydroxyoctadecanoic acid

ISSN: 1476-511X