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Fig. 5 | Lipids in Health and Disease

Fig. 5

From: Chemotherapy diminishes lipid storage capacity of adipose tissue in a preclinical model of colon cancer

Fig. 5

Schematic diagram summarizing adipose tissue alterations in rats undergoing 2-cycles of chemotherapy. Expression of many proteins within adipose tissue are altered in response to chemotherapy, which are mainly related to mitochondrial function. Mitochondrial dysfunction associates with decreased expression of proteins involved in ATP generation, fatty acid β-oxidation, Krebs cycle and acetyl-CoA production inside mitochondria. There was also a reduction in the expression of proteins in other metabolic pathways such as glycolysis, pentose phosphate, lipogenesis as well as decreased glucose uptake. Red arrows indicates reduced expression of proteins. Abbreviations: GLUT4, Glucose transporter-4; G-6-P, Glucose 6-phosphate; Fr 1,6-DP, Fructose 1,6-diphospate; GAP, Glyceraldehyde3-P; DHAP, Dihydroxyacetone phosphate; GDP1’ Glyceraldehyde-3-phosphate dehydrogenase; G3P, Glycerol-3-phosphate; TG, triglyceride; PL, Phospholipid; MUFA, Monounsaturated fatty acid; SCD1, Stearoyl-coenzyme A desaturase 1; FA, Fatty acid; HSL, Hormone-sensitive lipase; MPC2, Mitochondrial pyruvate carrier 2; SLC25A1, Solute carrier family 25 member 1; G6PD, Glucose-6-phosphate dehydrogenase; PGD, 6- phosphogluconate dehydrogenase; ACYL, ATP citrate lyase; ACC, Acetyl-coenzyme A carboxylase alpha; FAS, Fatty acid synthase

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