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Table 5 Demographic and biochemical features of T2DM patients according to the minor alleles of LEPR rs3806318 and rs1327118 polymorphisms

From: Association of polymorphisms in LEPR with type 2 diabetes and related metabolic traits in a Chinese population

Polymorphisms

Wild-type homozygous

Heterozygous + Mutated homozygous

Unadjusted P m/f; adjusted P m/f*

Unadjusted P; adjusted Pâ–³

Male

Female

Total

Male

Female

Total

rs1327118

CC(n = 726)

CG + GG(n = 196)

  

Sex(%)

293(40.3)

433(59.6)

726

68(34.7)

128(65.3)

196

–

0.161;-

Age(years)

63.8 ± 10.1

65.5 ± 10.0

64.8 ± 10.1

64.9 ± 10.6

65.1 ± 9.7

65.0 ± 9.9

0.442/0.719;-

0.781;-

BMI(kg/m2)a

25.3 ± 3.7

25.2 ± 3.7

25.2 ± 3.7

25.0 ± 3.0

24.6 ± 3.3

24.8 ± 3.2

0.526/0.113;0.557/0.107

0.091;0.099

SBP(mmHg)b

138.8 ± 20.4

138.4 ± 19.6

138.6 ± 19.9

139.6 ± 20.0

143.5 ± 20.0

142.2 ± 22.8

0.787/0.014;0.794/0.004

0.030;0.010

DBP(mmHg)b

82.9 ± 12.0

79.4 ± 10.6

80.8 ± 11.3

81.6 ± 13.2

81.8 ± 12.5

81.7 ± 12.7

0.441/0.032;0.500/0.026

0.327;0.181

FPG(mmol/L)b

7.8 ± 2.6

7.6 ± 2.6

7.6 ± 2.6

8.1 ± 2.6

7.6 ± 2.4

7.7 ± 2.5

0.399/0.934;0.384/0.879

0.613;0.555

HbA1c(%)b

6.7 ± 1.6

6.8 ± 1.6

6.7 ± 1.6

7.0 ± 1.6

6.8 ± 1.6

6.8 ± 1.6

0.230/0.845;0.264/0.966

0.570;0.536

HDL-C(mmol/L)b

1.1 ± 0.3

1.33 ± 0.4

1.3 ± 0.4

1.1 ± 0.3

1.26 ± 0.3

1.2 ± 0.3

0.692/0.056;0.397/0.033

0.141;0.024

LDL-C(mmol/L)b

2.9 ± 1.0

3.2 ± 1.0

3.1 ± 1.0

3.0 ± 1.1

3.2 ± 1.0

3.1 ± 1.1

0.586/0.916;0.973/0.886

0.685;0.862

TG(mmol/L)b

2.0 ± 1.8

2.0 ± 1.6

2.0 ± 1.7

2.1 ± 1.1

1.9 ± 1.4

2.0 ± 1.7

0.640/0.472;0.498/0.543

0.819;0.908

TC(mmol/L)b

4.9 ± 1.3

5.6 ± 1.5

5.3 ± 1.5

5.0 ± 1.4

5.4 ± 1.5

5.3 ± 1.5

0.468/0.422;0.804/0.313

0.971;0.431

rs3806318

AA(n = 741)

GA + GG (n = 184)

  

Sex(%)

287(38.7)

454(61.3)

741

76(41.3)

108(58.7)

184

–

0.555;-

Age(years)

63.8 ± 10.1

65.5 ± 10.1

64.9 ± 10.1

64.6 ± 10.4

65.0 ± 9.5

64.8 ± 9.8

0.568/0.531;-

0.957;-

BMI(kg/m2)a

25.4 ± 3.6

25.1 ± 3.6

25.2 ± 3.6

24.8 ± 3.5

24.8 ± 3.5

24.8 ± 3.5

0.188/0.419;0.197/0.399

0.147;0.139

SBP(mmHg)b

138.3 ± 20.3

139.4 ± 21.0

139.0 ± 20.7

141.3 ± 20.3

140.2 ± 19.7

140.6 ± 19.9

0.255/0.731;0.177/0.583

0.330;0.214

DBP(mmHg)b

82.1 ± 12.3

79.8 ± 11.4

80.7 ± 11.8

84.9 ± 11.8

80.4 ± 10.1

82.2 ± 11.0

0.075/0.659;0.033/0.580

0.116;0.076

FPG(mmol/L)b

7.9 ± 2.7

7.6 ± 2.6

7.7 ± 2.6

7.6 ± 2.5

7.4 ± 2.4

7.5 ± 2.5

0.390/0.562;0.423/0.548

0.336;0.310

HbA1c(%)b

6.8 ± 1.6

6.8 ± 1.6

6.8 ± 1.6

6.6 ± 1.5

6.8 ± 1.5

6.7 ± 1.5

0.313/0.818;0.285/0.781

0.647;0.669

HDL-C(mmol/L)b

1.1 ± 0.3

1.3 ± 0.4

1.2 ± 0.4

1.2 ± 0.4

1.3 ± 0.4

1.3 ± 0.4

0.103/0.409;0.151/0.493

0.148;0.153

LDL-C(mmol/L)b

2.9 ± 1.1

3.2 ± 1.0

3.1 ± 1.1

3.0 ± 0.9

3.3 ± 1.0

3.2 ± 1.0

0.432/0.213;0.413/0.178

0.175;0.116

TG(mmol/L)b

2.0 ± 1.9

1.9 ± 1.5

2.0 ± 1.7

1.9 ± 1.5

2.1 ± 1.5

2.0 ± 1.5

0.598/0.351;0.680/0.353

0.773;0.807

TC(mmol/L)b

4.9 ± 1.3

5.5 ± 1.5

5.2 ± 1.5

5.0 ± 1.3

5.7 ± 1.5

5.4 ± 1.4

0.368/0.117;0.396/0.067

0.107;0.053

  1. BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, FPG fasting plasma glucose, HbA1c Hemoglobin A1c, HDL-C HDL cholesterol, LDL-C LDL cholesterol, TG triglyceride, TC total cholesterol
  2. M, male; f, female; Unadjusted P values was obtained by chi-square test or student’s test; Adjusted P values was obtained by general linear model analysis after adjusting for covariates. However, the gender covariate was not included in after stratification by gender
  3. aadjusted for age and gender
  4. badjusted for age, gender and BMI
  5. *Results after stratification by gender
  6. â–³Results for the total sample
  7. P values in boldface are significant
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Lipids in Health and Disease

ISSN: 1476-511X