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Table 5 Demographic and biochemical features of T2DM patients according to the minor alleles of LEPR rs3806318 and rs1327118 polymorphisms

From: Association of polymorphisms in LEPR with type 2 diabetes and related metabolic traits in a Chinese population

Polymorphisms Wild-type homozygous Heterozygous + Mutated homozygous Unadjusted P m/f; adjusted P m/f* Unadjusted P; adjusted P
Male Female Total Male Female Total
rs1327118 CC(n = 726) CG + GG(n = 196)   
Sex(%) 293(40.3) 433(59.6) 726 68(34.7) 128(65.3) 196 0.161;-
Age(years) 63.8 ± 10.1 65.5 ± 10.0 64.8 ± 10.1 64.9 ± 10.6 65.1 ± 9.7 65.0 ± 9.9 0.442/0.719;- 0.781;-
BMI(kg/m2)a 25.3 ± 3.7 25.2 ± 3.7 25.2 ± 3.7 25.0 ± 3.0 24.6 ± 3.3 24.8 ± 3.2 0.526/0.113;0.557/0.107 0.091;0.099
SBP(mmHg)b 138.8 ± 20.4 138.4 ± 19.6 138.6 ± 19.9 139.6 ± 20.0 143.5 ± 20.0 142.2 ± 22.8 0.787/0.014;0.794/0.004 0.030;0.010
DBP(mmHg)b 82.9 ± 12.0 79.4 ± 10.6 80.8 ± 11.3 81.6 ± 13.2 81.8 ± 12.5 81.7 ± 12.7 0.441/0.032;0.500/0.026 0.327;0.181
FPG(mmol/L)b 7.8 ± 2.6 7.6 ± 2.6 7.6 ± 2.6 8.1 ± 2.6 7.6 ± 2.4 7.7 ± 2.5 0.399/0.934;0.384/0.879 0.613;0.555
HbA1c(%)b 6.7 ± 1.6 6.8 ± 1.6 6.7 ± 1.6 7.0 ± 1.6 6.8 ± 1.6 6.8 ± 1.6 0.230/0.845;0.264/0.966 0.570;0.536
HDL-C(mmol/L)b 1.1 ± 0.3 1.33 ± 0.4 1.3 ± 0.4 1.1 ± 0.3 1.26 ± 0.3 1.2 ± 0.3 0.692/0.056;0.397/0.033 0.141;0.024
LDL-C(mmol/L)b 2.9 ± 1.0 3.2 ± 1.0 3.1 ± 1.0 3.0 ± 1.1 3.2 ± 1.0 3.1 ± 1.1 0.586/0.916;0.973/0.886 0.685;0.862
TG(mmol/L)b 2.0 ± 1.8 2.0 ± 1.6 2.0 ± 1.7 2.1 ± 1.1 1.9 ± 1.4 2.0 ± 1.7 0.640/0.472;0.498/0.543 0.819;0.908
TC(mmol/L)b 4.9 ± 1.3 5.6 ± 1.5 5.3 ± 1.5 5.0 ± 1.4 5.4 ± 1.5 5.3 ± 1.5 0.468/0.422;0.804/0.313 0.971;0.431
rs3806318 AA(n = 741) GA + GG (n = 184)   
Sex(%) 287(38.7) 454(61.3) 741 76(41.3) 108(58.7) 184 0.555;-
Age(years) 63.8 ± 10.1 65.5 ± 10.1 64.9 ± 10.1 64.6 ± 10.4 65.0 ± 9.5 64.8 ± 9.8 0.568/0.531;- 0.957;-
BMI(kg/m2)a 25.4 ± 3.6 25.1 ± 3.6 25.2 ± 3.6 24.8 ± 3.5 24.8 ± 3.5 24.8 ± 3.5 0.188/0.419;0.197/0.399 0.147;0.139
SBP(mmHg)b 138.3 ± 20.3 139.4 ± 21.0 139.0 ± 20.7 141.3 ± 20.3 140.2 ± 19.7 140.6 ± 19.9 0.255/0.731;0.177/0.583 0.330;0.214
DBP(mmHg)b 82.1 ± 12.3 79.8 ± 11.4 80.7 ± 11.8 84.9 ± 11.8 80.4 ± 10.1 82.2 ± 11.0 0.075/0.659;0.033/0.580 0.116;0.076
FPG(mmol/L)b 7.9 ± 2.7 7.6 ± 2.6 7.7 ± 2.6 7.6 ± 2.5 7.4 ± 2.4 7.5 ± 2.5 0.390/0.562;0.423/0.548 0.336;0.310
HbA1c(%)b 6.8 ± 1.6 6.8 ± 1.6 6.8 ± 1.6 6.6 ± 1.5 6.8 ± 1.5 6.7 ± 1.5 0.313/0.818;0.285/0.781 0.647;0.669
HDL-C(mmol/L)b 1.1 ± 0.3 1.3 ± 0.4 1.2 ± 0.4 1.2 ± 0.4 1.3 ± 0.4 1.3 ± 0.4 0.103/0.409;0.151/0.493 0.148;0.153
LDL-C(mmol/L)b 2.9 ± 1.1 3.2 ± 1.0 3.1 ± 1.1 3.0 ± 0.9 3.3 ± 1.0 3.2 ± 1.0 0.432/0.213;0.413/0.178 0.175;0.116
TG(mmol/L)b 2.0 ± 1.9 1.9 ± 1.5 2.0 ± 1.7 1.9 ± 1.5 2.1 ± 1.5 2.0 ± 1.5 0.598/0.351;0.680/0.353 0.773;0.807
TC(mmol/L)b 4.9 ± 1.3 5.5 ± 1.5 5.2 ± 1.5 5.0 ± 1.3 5.7 ± 1.5 5.4 ± 1.4 0.368/0.117;0.396/0.067 0.107;0.053
  1. BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, FPG fasting plasma glucose, HbA1c Hemoglobin A1c, HDL-C HDL cholesterol, LDL-C LDL cholesterol, TG triglyceride, TC total cholesterol
  2. M, male; f, female; Unadjusted P values was obtained by chi-square test or student’s test; Adjusted P values was obtained by general linear model analysis after adjusting for covariates. However, the gender covariate was not included in after stratification by gender
  3. aadjusted for age and gender
  4. badjusted for age, gender and BMI
  5. *Results after stratification by gender
  6. Results for the total sample
  7. P values in boldface are significant