Association between KIF6 rs20455 polymorphism and the risk of coronary heart disease (CHD): a pooled analysis of 50 individual studies including 40,059 cases and 64,032 controls

Li, Yan; Chen, Zhen; Song, Hejian

doi:10.1186/s12944-017-0651-y

Lipids in Health and Disease

Table 2 Main results of pooled ORs with 95% CI in the meta-analysis

From: Association between KIF6 rs20455 polymorphism and the risk of coronary heart disease (CHD): a pooled analysis of 50 individual studies including 40,059 cases and 64,032 controls

Variables	No.	P_heterogneity	Analysis model	OR (95% CI)	P	P_Begg’s	P_Egger’s
Homozygote model
Total	50	0.012	Random model	1.007 (0.952–1.066)	0.801	0.106	0.108
Ethnicity
Caucasian	37	0.45	Fixed model	1.012 (0.964–1.063)	0.622
Asian	9	0.158	Fixed model	1.038 (0.933–1.154)	0.494
Mixed	4	0.004	Random model	0.771 (0.57–1.043)	0.0731
Source of control
PB	20	0.038	Random model	0.981 (0.895–1.076)	0.691
HB	21	0.096	Fixed model	1.027 (0.956–1.103)	0.891
FB	4	0.038	Fixed model	0.907 (0.767–1.072)	0.016
CB	3	0.427	Fixed model	1.019 (0.872–1.189)	0.816
H-CB	2	0.368	Fixed model	1.073 (0.895–1.286)	0.446
Heterozygote model
Total	50	0.008	Random model	1.009 (0.968–1.052)	0.636	0.089	0.070
Ethnicity
Caucasian	37	0.035	Random model	0.955 (0.963–1.029)	0.790
Asian	9	0.071	Fixed model	1.089 (0.995–1.191)	0.065
Mixed	4	0.639	Fixed model	0.893 (0.799–0.999)	0.047
Source of control
PB	20	0.067	Random model	0.979 (0.938–1.021)	0.316
HB	21	0.004	Random model	1.040 (0.956–1.132)	0.356
FB	4	0.807	Fixed model	0.966 (0.859–1.085)	0.558
CB	3	0.924	Fixed model	1.064 (0.957–1.183)	0.254
H-CB	2	0.265	Fixed model	0.967 (0.841–1.112)	0.637
Dominant model
Total	50	0.002	Random model	1.007 (0.966–1.048)	0.753	0.061	0.058
Ethnicity
Caucasian	37	0.034	Random model	1.013 (0.970–1.057)	0.568
Asian	9	0.054	Fixed model	1.071 (0.984–1.165)	0.112
Mixed	4	0.508	Fixed model	0.854 (0.770–0.947)	0.003
Source of control
PB	20	0.026	Random model	0.991 (0.932–1.055)	0.786
HB	21	0.002	Random model	1.040 (0.958–1.129)	0.346
FB	4	0.820	Fixed model	0.948 (0.848–1.059)	0.342
CB	3	0.986	Fixed model	1.053 (0.953–1.164)	0.310
H-CB	2	0.551	Fixed model	0.993 (0.871–1.132)	0.917
Recessive model
Total	50	0.047	Random model	0.989 (0.943–1.037)	0.655	0.025	0.040
Ethnicity
Caucasian	37	0.541	Fixed model	1.002 (0.959–1.048)	0.919
Asian	9	0.819	Fixed model	0.983 (0.898–1.075)	0.705
Mixed	4	<0.001	Random model	0.811 (0.592–1.111)	0.191
Source of control
PB	20	0.040	Random model	0.982 (0.902–1.069)	0.668
HB	21	0.796	Fixed model	0.989 (0.919–1.064)	0.715
FB	4	0.004	Random model	0.924 (0.661–1.291)	0.643
CB	3	0.287	Fixed model	1.009 (0.843–1.209)	0.883
H-CB	2	0.142	Fixed model	1.099 (0.856–1.412)	0.395
Allele comparison model
Total	50	0.001	Random model	1.00 (0.971–1.030)	0.988	0.052	0.066
Ethnicity
Caucasian	37	0.067	Fixed model	0.999 (0.977–1.022)	0.950
Asian	9	0.186	Fixed model	1.022 (0.968–1.079)	0.428
Mixed	4	0.009	Random model	0.855 (0.742–0.985)	<0.001
Source of control
PB	20	0.004	Random model	0.990 (0.943–1.040)	0.690
HB	21	0.017	Random model	1.015 (0.967–1.066)	0.547
FB	4	0.045	Random model	0.877 (0.691–1.113)	0.361
CB	3	0.653	Fixed model	1.025 (0.953–1.102)	0.507
H-CB	2	0.776	Fixed model	1.019 (0.931–1.115)	0.687

No. number of studies, OR odds ratio, 95% CI 95% confidence interval, HB hospital based study, PB population based study, FB family based study, CB community based study, H-CB hospital and community based study

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