Table 2 Multivariate associations of the pre-miR-27a rs895819 with the risk of MI
Model | Genotype | Cases (n = 287) | Controls (n = 646) | OR (95% CI) a | P a |
|---|---|---|---|---|---|
No. (%) | No. (%) | ||||
pre-miR-27a rs895819 HWE b : 0.4179 | |||||
 Allele | G | 160 (27.9) | 325 (25.2) | 1.00 |  |
A | 414 (72.1) | 967 (74.8) | 0.77 (0.60-1.01) | 0.055 | |
 Genotype | GG | 29 (10.1) | 37 (5.7) | 1.00 |  |
AG | 102 (35.5) | 251 (38.9) | 0.40 (0.21-0.76) | 0.005 | |
AA | 156 (54.4) | 358 (55.4) | 0.40 (0.22-0.75) | 0.004 | |
 Dominant | AG + GG | 288 (44.6) | 131 (45.6) | 1.00 |  |
AA | 156 (54.4) | 358 (55.4) | 0.86 (0.62-1.21) | 0.389 | |
 Recessive | GG | 29 (10.1) | 37 (5.7) | 1.00 |  |
AG + AA | 258 (89.9) | 609 (94.3) | 0.40 (0.22-0.74) | 0.003 | |
pri-miR-26a-1 rs7372209 HWE: 0.7195 | |||||
 Allele | C | 433 (75.4) | 980 (75.9) | 1.00 |  |
T | 141 (24.6) | 312 (24.1) | 0.98 (0.74-1.29) | 0.879 | |
 Genotype | TT | 16 (5.6) | 36 (5.6) | 1.00 |  |
CT | 109 (38.0) | 240 (37.2) | 1.26 (0.58-2.76) | 0.556 | |
CC | 162 (56.4) | 370 (57.3) | 1.21 (0.57-2.60) | 0.619 | |
 Dominant | CC | 162 (56.4) | 370 (57.3) | 1.00 |  |
CT + TT | 125 (43.6) | 276 (42.7) | 1.01 (0.72-1.42) | 0.947 | |
 Recessive | TT | 16 (5.6) | 36 (5.6) | 1.00 |  |
CT + CC | 271 (94.4) | 610 (94.4) | 1.23 (0.58-2.61) | 0.585 | |
pri-miR-100 rs1834306 HWE: 0.2017 | |||||
 Allele | C | 341 (59.4) | 742 (57.4) | 1.00 |  |
T | 233 (40.6) | 550 (42.6) | 0.97 (0.77-1.23) | 0.816 | |
 Genotype | TT | 45 (15.7) | 125 (19.3) | 1.00 |  |
CT | 143 (49.8) | 300 (46.4) | 1.28 (0.80-2.05) | 0.303 | |
CC | 99 (34.5) | 221 (34.2) | 1.13 (0.69-1.85) | 0.628 | |
 Dominant | TT | 45 (15.7) | 125 (19.3) | 1.00 |  |
CT + CC | 242 (84.3) | 521 (80.7) | 1.22 (0.78-1.90) | 0.391 | |
 Recessive | CC | 99 (34.5) | 221 (34.2) | 1.00 |  |
CT + TT | 188 (65.5) | 425 (65.8) | 1.06 (0.75-1.51) | 0.733 | |
pri-miR-126 rs4636297 HWE: 0.4457 | |||||
 Allele | G | 497 (86.6) | 1106 (85.6) | 1.00 |  |
A | 77 (13.4) | 186 (14.4) | 0.95 (0.68-1.33) | 0.755 | |
 Genotype | GG | 216 (75.3) | 471 (72.9) | 1.00 |  |
AG | 65 (22.6) | 164 (25.4) | 1.01 (0.69-1.48) | 0.951 | |
AA | 6 (2.1) | 11 (1.7) | 1.44 (0.41-5.10) | 0.569 | |
 Dominant | AG + GG | 281 (97.9) | 635 (98.3) | 1.00 |  |
AA | 6 (2.1) | 11 (1.7) | 1.44 (0.41-5.07) | 0.571 | |
 Recessive | GG | 216 (75.3) | 471 (72.9) | 1.00 |  |
AG + AA | 71 (24.7) | 175 (27.1) | 1.04 (0.71-1.50) | 0.857 | |
pri-miR-218 rs11134527 HWE: 0.4264 | |||||
 Allele | A | 331 (57.7) | 726 (56.2) | 1.00 |  |
G | 243 (42.3) | 566 (43.8) | 1.08 (0.84-1.38) | 0.563 | |
 Genotype | AA | 85 (29.6) | 199 (30.8) | 1.00 |  |
AG | 161 (56.1) | 328 (50.8) | 1.27 (0.87-1.85) | 0.213 | |
GG | 41 (14.3) | 119 (18.4) | 1.08 (0.65-1.80) | 0.771 | |
 Dominant | GG | 41 (14.3) | 119 (18.4) | 1.00 |  |
AG + AA | 246 (85.7) | 527 (81.6) | 1.08 (0.69-1.70) | 0.744 | |
 Recessive | AA | 85 (29.6) | 199 (30.8) | 1.00 |  |
AG + GG | 202 (70.4) | 447 (69.2) | 1.22 (0.85-1.76) | 0.273 | |