Circulating PCSK9 levels and 2-hPG are positively correlated in metabolic diseases in a Chinese Han population

Table 2 Spearman rank correlation between serum PCSK9 and different covariates in groups with different glucose tolerance

	All (n = 600)		NGT (n = 200)		IGR (n = 200)		T2DM (n = 200)
	r	p	r	p	r	p	r	p
Age(years)	0.086	0.035	0.105	0.138	0.113	0.112	0.034	0.629
SBP(mmHg)	0.113	0.006	−0.074	0.297	0.202	0.004	−0.012	0.866
DBP(mmHg)	0.016	0.695	−0.087	0.219	−0.007	0.922	−0.077	0.278
BMI(kg/m²)	0.180	<0.001	0.109	0.126	0.146	0.039	0.101	0.157
WC(cm)	0.131	0.001	0.068	0.343	0.051	0.476	0.094	0.190
HC(cm)	0.101	0.014	0.153	0.032	0.048	0.503	0.025	0.729
WHR	0.103	0.013	−0.028	0.701	0.038	0.590	0.120	0.095
HR	0.174	<0.001	0.171	0.016	0.101	0.153	0.039	0.582
HDL-C(mmol/L)	−0.042	0.309	−0.025	0.729	0.071	0.314	−0.038	0.590
LDL-C(mmol/L)	0.192	<0.001	0.194	0.006	0.201	0.004	0.145	0.040
TC(mmol/L)	0.134	0.001	0.100	0.159	0.164	0.021	0.136	0.055
TG(mmol/L)	0.165	0.001	0.047	0.505	0.055	0.443	0.166	0.019
FBG(mmol/L)	0.266	<0.001	−0.008	0.915	−0.039	0.583	0.223	0.001
2-hPG(mmol/L)	0.426	<0.001	0.215	0.002	0.512	0.001	0.323	<0.001
FINS(μIU/ml)	0.249	<0.001	0.096	0.175	0.214	0.002	0.243	0.001
2 h–INS(μIU/ml)	0.231	<0.001	0.149	0.035	0.306	<0.001	−0.007	0.916
HOMA-IR	0.294	<0.001	0.099	0.163	0.176	0.013	0.312	<0.001

SBP systolic blood pressure, DBP diastolic blood pressure, BMI body mass index, WC waist circumference, HC hip circumference, WHR waist-to-hip ratio, HR heart rate, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, TC total cholesterol, TG triglyceride, FBG fasting bloodglucose, 2-hPG 2-h postchallenge plasma glucose, FINS fasting insulin, 2 h–INS 2-hpostchallenge plasma insulin, PCSK9 Preproteinconvertasesubtilisin/kexin type 9, HOMA-IR homeostasis model assessment-estimated insulin resistance index
^ap < 0.05, ^bp < 0.01

ISSN: 1476-511X