Diet/lifestyle and risk of diabetes and glycemic traits: a Mendelian randomization study

Ding, Renyu; Huang, Tao; Han, Jiali

doi:10.1186/s12944-018-0666-z

Lipids in Health and Disease

Table 2 Lifestyle associated SNPs and glycemic traits

From: Diet/lifestyle and risk of diabetes and glycemic traits: a Mendelian randomization study

Lifestyle	Lifestyle-Associated SNP	T2D [10]		HOMA-IR [11]		HOMA-B [11]		INS [11]		GLU [11]		Hba1c [12]		2hGLU [13]
Lifestyle	Lifestyle-Associated SNP	Beta ± SE	p	Beta ± SE	p	Beta ± SE	p	Beta ± SE	p	Beta ± SE	p	Beta ± SE	p	Beta ± SE	p
Carbohydrate	rs10163409	0.020 ± 0.018	0.370	0.006 ± 0.005	0.201	0.002 ± 0.004	0.580	0.004 ± 0.005	0.327	0.004 ± 0.004	0.309	− 0.008 ± 0.004	0.041	0.015 ± 0.022	0.495
Carbohydrate	rs197273	0.000 ± 0.015	0.970	−0.002 ± 0.004	0.606	− 0.005 ± 0.003	0.159	− 0.002 ± 0.004	0.667	0.003 ± 0.004	0.500	0.002 ± 0.004	0.609	0.021 ± 0.019	0.280
Carbohydrate	rs838145	0.020 ± 0.017	0.230	−0.002 ± 0.004	0.716	0.003 ± 0.003	0.405	−0.001 ± 0.004	0.879	0.001 ± 0.004	0.720	0.005 ± 0.004	0.165	−0.013 ± 0.020	0.498
Protein	rs1421085	0.104 ± 0.014	4.40 × 10–11	0.016 ± 0.004	9.55 × 10–5	0.008 ± 0.003	0.020	−0.015 ± 0.004	7.48 × 10–5	0.007 ± 0.004	0.053	0.008 ± 0.004	0.028	−0.001 ± 0.019	0.981
Protein	rs838133	0.010 ± 0.018	0.720	0.002 ± 0.005	0.626	0.002 ± 0.004	0.546	0.001 ± 0.004	0.904	0.001 ± 0.004	0.805	−0.006 ± 0.004	0.153	0.013 ± 0.021	0.534
Fat	rs838145	−0.020 ± 0.017	0.230	0.002 ± 0.004	0.716	0.003 ± 0.003	0.405	0.001 ± 0.004	0.879	−0.001 ± 0.004	0.720	−0.005 ± 0.004	0.165	0.013 ± 0.020	0.498
Sleep	rs1191685	−0.010 ± 0.015	0.370	0.002 ± 0.005	0.655	0.004 ± 0.004	0.270	0.002 ± 0.005	0.701	−0.005 ± 0.004	0.225	−0.006 ± 0.004	0.119	0.028 ± 0.021	0.184
Sleep	rs2394403	0.030 ± 0.015	0.094	0.002 ± 0.005	0.685	0.003 ± 0.005	0.464	0.001 ± 0.005	0.840	−0.002 ± 0.005	0.676	−0.003 ± 0.005	0.482	0.002 ± 0.026	0.943
Sleep	rs4248149	0.030 ± 0.015	0.076	0.002 ± 0.006	0.783	0.002 ± 0.005	0.655	0.000 ± 0.005	0.934	−0.001 ± 0.005	0.821	−0.002 ± 0.005	0.747	−0.005 ± 0.027	0.849
Sleep	rs4587207	0.010 ± 0.015	0.670	0.001 ± 0.005	0.798	0.003 ± 0.005	0.456	0.000 ± 0.005	0.937	−0.003 ± 0.005	0.552	−0.003 ± 0.005	0.506	−0.002 ± 0.026	0.940
smoking (number)	rs1051730	−0.030 ± 0.017	0.035	0.003 ± 0.004	0.459	−0.002 ± 0.004	0.657	0.002 ± 0.004	0.663	0.003 ± 0.004	0.430	0.004 ± 0.004	0.281	0.001 ± 0.020	0.951
smoking (number)	rs1329650	0.010 ± 0.013	0.290	−0.008 ± 0.004	0.055	−0.004 ± 0.004	0.300	−0.006 ± 0.004	0.169	−0.005 ± 0.004	0.192	−0.005 ± 0.004	0.226	0.007 ± 0.020	0.742
smoking (number)	rs3733829	0.010 ± 0.015	0.410	0.002 ± 0.004	0.713	−0.002 ± 0.004	0.595	−0.001 ± 0.004	0.752	0.003 ± 0.004	0.418	0.003 ± 0.004	0.362	−0.016 ± 0.020	0.444
Smoking initiation	rs6265	0.010 ± 0.015	0.500	0.005 ± 0.005	0.346	0.003 ± 0.004	0.494	0.004 ± 0.005	0.392	0.001 ± 0.005	0.793	0.009 ± 0.004	0.042	−0.033 ± 0.024	0.166
Smoking cessation	rs3025343	0.068 ± 0.038	0.099	0.020 ± 0.008	0.010	0.008 ± 0.007	0.233	0.016 ± 0.008	0.032	0.016 ± 0.007	0.029	0.011 ± 0.007	0.093	0.038 ± 0.039	0.330

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