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Table 1 Effect of Nicotinamide, Vitamin B2 and Vitamin C on liver function parameters in plasma of thioactamide treated rats

From: Potential effects of the combination of nicotinamide, vitamin B2 and vitamin C on oxidative-mediated hepatotoxicity induced by thioacetamide

Treatment Parameter

Control

TAA

TAA + NA

TAA + VB2

TAA + VC

TAA + NA,VB2,VC

AST(U/l)

46.53 ± 1.08

269.36 ± 11.75a

137.64 ± 6.83a,b

142.43 ± 7.76a,b

170.34 ± 7.33a,b

95.17 ± 4.59a,b,c

ALT(U/l)

23.17 ± 1.34

153.46 ± 8.63a

114.56 ± 4.78a,b

109.89 ± 9.32a,b

94.57 ± 3.21a,b

65.46 ± 1.96a,b,c

ALP(U/l)

150.46 ± 10.06

676.35 ± 21.67a

470.48 ± 26.41a,b

418.34 ± 15.68a,b

580.41 ± 19.73a,b

242.00 ± 15.47a,b,c

LDH

212.55 ± 8.69

802.40 ± 4.75a

512.07 ± 18.67a,b

450.82 ± 14.25a,b

478.16 ± 17.56a,b

275.44 ± 12.49a,b,c

Total bilirubin(mg/dl)

0.43 ± 0.01

0.91 ± 0.03a

0.63 ± 0.01a,b

0.70 ± 0.04a,b

0.66 ± 0.03a,b

0.54 ± 0.02a,b,c

Total protein(g/dl)

7.34 ± 1.58

5.27 ± 0.10a

5.88 ± 0.19a,b

6.09 ± 0.27a,b

6.47 ± 0.34a,b

7.55 ± 0.10a,b,c

  1. aSignificant difference from control
  2. bSignificant difference from TAA group
  3. cSignificant difference from TAA + NA, TAA + VB2, TAA + VC