Fig. 2

SERCA activity in sham and overloaded (OVL) plantaris muscles. (a) Representative SERCA activity-pCa curves. (b) Maximal SERCA activity is reduced in the overloaded plantaris. (c) SERCA’s apparent affinity for calcium is unaltered in the overloaded plantaris compared with sham. *Significantly different from sham, p ≤ 0.05; (n = 6 per group). pCa₅₀ is the negative logarithm of [Ca²⁺] required to elicit half maximal SERCA activity