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Table 3 Metabolic parameters and thyroid hormones in treatment groups before and after intervention

From: Powdered black cumin seeds strongly improves serum lipids, atherogenic index of plasma and modulates anthropometric features in patients with Hashimoto’s thyroiditis

N Powdered Black Cumin Treated Placebo treated P
N = 20 N = 20
FSG (mg/dl)
 Before 86.60 ± 8.46 88.10 ± 8.56 0.58
 After 84.90 ± 7.01 87.80 ± 6.03 0.16
P‡ 0.31 0.85  
Insulin (μIU/ml)
 Before 10.62 ± 7.51 7.71 ± 4.12 0.14
 After 29.18 ± 19.93 17.30 ± 9.16 0.023
P‡ < 0.001 < 0.001  
HOMA-IR
 Before 2.32 ± 1.71 1.67 ± 0.92 0.14
 After 6.09 ± 4.06 3.76 ± 2.08 0.03
P‡ < 0.001 < 0.001  
HDL (mg/dl)
 Before 41.55 ± 4.67 41.70 ± 6.50 0.93
 After 43.75 ± 3.72 40.57 ± 4.87 0.027
P‡ 0.046 0.26  
LDL (mg/dl)
 Before 130.65 ± 30.68 105.00 ± 34.48 0.018
 After 107.85 ± 36.99 108.90 ± 32.88 0.92
P‡ 0.002 0.06  
TG (mg/dl)
 Before 177.10 ± 34.50 186.00 ± 66.63 0.59
 After 156.00 ± 21.92 185.55 ± 74.98 0.11
P‡ 0.02 0.93  
TC (mg/dl)
 Before 183.70 ± 45.72 179.10 ± 43.66 0.74
 After 175.10 ± 29.06 180.70 ± 44.95 0.64
P‡ 0.22 0.55  
AIP
 Before 0.62 ± 0.11 0.63 ± 0.15 0.86
 After 0.54 ± 0.08 0.63 ± 0.16 0.04
P‡ < 0.001 0.68  
Nesfatin-1 (ng/ml)
 Before 41.80 ± 28.33 25.86 ± 20.91 0.049
 After 37.63 ± 5.91 26.75 ± 23.95 0.175
P‡ 0.34 0.69  
TSH (mIU/l)
 Before 6.42 ± 3.86 8.14 ± 7.28 0.35
 After 4.13 ± 2.35 8.27 ± 7.21 0.02
P‡ 0.03 0.40  
T3 (mmol/l)
 Before 0.92 ± 0.27 1.18 ± 0.36 0.017
 After 1.06 ± 0.34 1.16 ± 0.35 0.39
P‡ 0.008 0.15  
T4 (mmol/l)
 Before 8.07 ± 2.56 7.97 ± 3.11 0.91
 After 8.89 ± 1.43 7.63 ± 2.23 0.04
P‡ 0.21 0.32  
Anti-TPO (IU/ml)
 Before 294.55 ± 210.05 278.10 ± 170.77 0.78
 After 147.99 ± 158.33 274.30 ± 167.20 0.01
P‡ 0.019 0.28  
  1. Data are presented as mean ± SD. P values for ANCOVA after adjustment for age, duration of the disease and baseline concentration of parameter; ‡P values for paired t-test. FSG fasting serum glucose, TC total cholesterol, TG triglycerides, HDL high-density lipoprotein cholesterol, AIP atherogenic index of plasma, TSH thyroid-stimulating hormone, T3 triiodothyronine T4 thyroxine, TPO thyroid peroxidase
  2. The bold data present the statistically significant values