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Table 4 Predictors for Cardiovascular events according to Cox’s proportional hazard analysis

From: Effects of statin therapy on chronic kidney disease patients with coronary artery disease

Variables   Unadjusted    Adjusted  
HR 95% CI P HR 95% CI P
CKD versus CKD + CAD 0.5 (0.27–0.68) < 0.001 0.46 (0.25–0.59) < 0.001
Age (years) 1.32 (1.21–1.93) < 0.001 1.1 (0.95–1.04) 0.078
Male (versus female) 0.76 (0.57–1.15) 0.545   
Hypertension 1.61 (1.21–2.01) < 0.01 1.16 (0.95–1.67) 0.071
Diabetes mellitus 1.24 (0.87–1.72) 0.291   
Smoking 1.43 (1.33–1.81) < 0.01 1.41 (1.09–2.11) 0.009
Myocardial infarction 1.18 (1.06–1.89) 0.048 1.03 (0.91–1.35) 0.121
Angina pectoris 1.07 (0.67–1.46) 0.32   
Stroke 1.53 (0.97–3.16) 0.221   
Calcium-channel blocker 1.27 (0.76–1.50) 0.322   
ACEI 0.97 (0.85–1.30) 0.976   
ARB 0.89 (0.63–1.28) 0.514   
β-blocker 1.42 (1.12–1.89) < 0.01 1.11 (0.72–1.61) 0.55
Loop diuretic 1.09 (0.61–1.76) 0.488   
Aspirin 1.98 (1.56–3.97) < 0.01 1.32 (0.68–1.99) 0.601
Triglycerides (mmol/l) 1.12 (0.72–1.81) 0.78   
Total cholesterol (mmol/l) 1.07 (0.87–1.75) 0.64   
LDL-C (mmol/l) 1.12 (1.07–1.62) < 0.001 1.05 (1.01–1.25) 0.011
HDL-C (mmol/l) 0.69 (0.46–1.21) 0.222   
Glucose (mmol/l) 1.23 (0.96–1.91) 0.52   
HbA1c (%) 0.96 (0.68–1.69) 0.771   
SBP (mmHg) 0.97 (0.90–1.18) 0.078   
DBP (mmHg) 1.08 (0.97–1.39) 0.56   
Long-term statins 0.22 (0.19–0.57) < 0.001 0.27 (0.21–0.41) < 0.001
  1. CAD coronary artery disease, CKD chronic kidney disease, ACEI angiotensin-converting enzyme inhibitor, ARB angiotensin-receptor blocker, SBP systolic blood pressure, DBP diastolic blood pressure, HbA1c hemoglobin A1c, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol