Associations between three common single nucleotide polymorphisms (rs266729, rs2241766, and rs1501299) of ADIPOQ and cardiovascular disease: a meta-analysis

Kanu, Joseph Sam; Qiu, Shuang; Cheng, Yi; Li, Ri; Kou, Changgui; Gu, Yulu; Bai, Ye; Shi, Jikang; Li, Yong; Liu, Yunkai; Yu, Yaqin; Liu, Yawen

doi:10.1186/s12944-018-0767-8

Lipids in Health and Disease

Table 2 Overall and subgroup meta-analysis of the association between ADIPOQ rs266729, −11,377 C > G polymorphisms and CVD

From: Associations between three common single nucleotide polymorphisms (rs266729, rs2241766, and rs1501299) of ADIPOQ and cardiovascular disease: a meta-analysis

Categories	n	Sample size	G VS C			GG + GC VS CC			GG VS GC + CC			GC VS CC			GG VS CC
Categories	n	Case/Control	OR (95% CI)	P	I²⁽%)/Ph	OR (95% CI)	P	I²⁽%)/Ph	OR (95% CI)	P	I²⁽%)/Ph	OR (95% CI)	P	I²⁽%)/Ph	OR (95% CI)	P	I²⁽%)/Ph
Overall	29	10,506/18,515	1.079 (1.000, 1.165)	0.051	65.8/0.000	1.129 (1.028, 1.239)	0.011	64.5/0.000	0.989 (0.838, 1.168)	0.898	48.5/0.002	1.141 (1.041, 1.250)	0.005	59.9/0.000	1.037 (0.867, 1.239)	0.692	53.4/0.000
Population
European	17	6,355/11,666	1.022 (0.948, 1.102)	0.564	37.6/0.060	1.071 (0.974, 1.178)	0.158	40.8/0.041	0.879 (0.714, 1.082)	0.224	40.0/0.045	1.102 (0.995, 1.220)	0.062	43.5/0.029	0.908 (0.739, 1.116)	0.360	36.9/0.064
East Asian	12	4,151/6,849	1.154 (1.000, 1.332)	0.051	76.8/0.000	1.198 (1.006, 1.427)	0.043	75.7/0.000	1.149 (0.887, 1.487)	0.293	52.5/0.017	1.184 (1.002, 1.398)	0.048	70.7/0.000	1.231 (0.919, 1.650)	0.164	61.4/0.003
Genotyping
PCR-RFLP	8	2,382/4,976	1.186 (0.978, 1.438)	0.083	77.5/0.000	1.276 (1.014, 1.607)	0.038	75.4/0.000	1.162 (0.813, 1.661)	0.411	53.5/0.035	1.282 (1.032, 1.592)	0.025	69.7/0.002	1.285 (0.859, 1.922)	0.223	61.3/0.011
TaqMan	12	3,910/6,312	1.031 (0.935, 1.137)	0.544	45.3/0.044	1.054 (0.948, 1.173)	0.331	30.7/0.146	0.951 (0.720, 1.256)	0.721	53.5/0.014	1.064 (0.960, 1.180)	0.236	20.6/0.242	0.973 (0.735, 1.288)	0.849	52.2/0.018
Others	9	4,214/7,227	1.045 (0.921, 1.186)	0.493	63.6/0.005	1.095 (0.926, 1.296)	0.289	68.7/0.001	0.923 (0.711, 1.197)	0.545	39.6/0.103	1.121 (0.941, 1.336)	0.201	68.7/0.001	0.949 (0.717, 1.255)	0.713	44.9/0.069
Sample size
< 1000	21	5,048/6,708	1.065 (0.952, 1.192)	0.270	67.9/0.000	1.114 (0.973, 1.276)	0.119	65.9/0.000	0.955 (0.744, 1.228)	0.722	53.4/0.002	1.128 (0.988, 1.287)	0.075	60.9/0.000	0.992 (0.759, 1.298)	0.956	57.6/0.001
≥ 1000	8	5,458/11,807	1.108 (1.004, 1.222)	0.042	63.4/0.008	1.162 (1.026, 1.315)	0.018	64.6/0.006	1.017 (0.835, 1.240)	0.864	38.6/0.122	1.172 (1.035, 1.326)	0.012	61.5/0.011	1.087 (0.877, 1.347)	0.445	45.4/0.077
Quality score
< 10	16	3,489/5,128	1.152 (1.007, 1.318)	0.040	68.0/0.000	1.211 (1.032, 1.420)	0.019	64.6/0.000	1.147 (0.861, 1.528)	0.348	49.6/0.013	1.207 (1.036, 1.406)	0.016	57.8/0.002	1.215 (0.888, 1.664)	0.224	55.9/0.003
≥ 10	13	7,017/13,387	1.019 (0.940, 1.105)	0.646	55.5/0.008	1.062 (0.954, 1.182)	0.271	61.3/0.002	0.883 (0.744, 1.048)	0.155	31.5/0.131	1.089 (0.974, 1.219)	0.135	61.8/0.002	0.915 (0.767, 1.093)	0.327	33.5/0.115

n study numbers, Bold values represent statistically significant findings

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