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Table 2 Estimation of the standardized difference means of related indictors with CI 95% between the intervention and placebo groups

From: The effects of inositol supplementation on lipid profiles among patients with metabolic diseases: a systematic review and meta-analysis of randomized controlled trials

Variables Number of study Standardized mean difference CI 95% Heterogeneity
I-squared (%) Q P-value
Triglycerides Intervention group (after vs. before) 12 − 1.84 − 2.62, − 1.06 95.6 248.31 < 0.001
Placebo group (after vs. before) 12 − 0.17 − 0.39, 0.05 53.9 23.84 0.01
Intervention group vs. placebo group 12 − 1.24 − 1.84, − 0.64 93.2 161.55 < 0.001
Total cholesterol Intervention group (after vs. before) 11 − 1.40 − 2.11, − 0.69 94.7 189.67 < 0.001
Placebo group (after vs. before) 11 0.22 −0.17, 0.61 84.7 65.30 < 0.001
Intervention group vs. placebo group 11 −1.19 − 1.83, −0.55 93.6 156.53 < 0.001
LDL-cholesterol Intervention group (after vs. before) 5 −1.28 −2.37, −0.18 94.4 71.88 < 0.001
Placebo group (after vs. before) 5 0.23 0.02, 0.44 0.00 3.13 0.53
Intervention group vs. placebo group 5 −1.31 −2.23, −0.39 92.2 51.00 < 0.001
HDL-cholesterol Intervention group (after vs. before) 10 0.37 −0.13, 0.87 90.7 96.93 < 0.001
Placebo group (after vs. before) 10 −0.02 − 0.20, 0.15 27.2 12.37 0.19
Intervention group vs. placebo group 10 0.20 −0.27, 0.67 89.4 84.52 < 0.001