Table 3 Effect of δ-tocotrienol on down-regulation of fold change gene expression of “Molecules” section (64) of IPA analysis in hepatitis C patients
Down-regulation | ||||
|---|---|---|---|---|
# | Symbol | Entrez Gene Name | Expr Fold Change | Type(s) |
1 | ATP1A1 | ATPase Na+/K+ transporting subunit alpha 1 | -8.014 | transporter |
2 | HSP90AB1 | heat shock protein 90 alpha family class B member 1 | -8.049 | enzyme |
3 | APOBEC3A | apolipoprotein B mRNA editing enzyme catalytic subunit 3A | -8.163 | enzyme |
4 | CXCR2 | C-X-C motif chemokine receptor 2 | -8.208 | G-protein coupled receptor |
5 | IL16 | interleukin 16 | -8.239 | cytokine |
6 | PSMC3 | proteasome 26S subunit, ATPase 3 | -8.346 | transcription regulator |
7 | NDUFB9 | NADH:ubiquinone oxidoreductase subunit B9 | -8.354 | enzyme |
8 | CYB5R4 | cytochrome b5 reductase 4 | -8.367 | enzyme |
9 | ATG3 | autophagy related 3 | -8.376 | enzyme |
10 | CREB1 | cAMP responsive element binding protein 1 | -8.452 | transcription regulator |
12 | NDUFB1 | NADH:ubiquinone oxidoreductase subunit B1 | -8.566 | enzyme |
13 | PDE3B | phosphodiesterase 3B | -8.568 | enzyme |
14 | IGF2R | insulin like growth factor 2 receptor | -8.68 | transmembrane receptor |
15 | CYP2R1 | cytochrome P450 family 2 subfamily R member 1 | -8.682 | enzyme |
16 | NDUFA11 | NADH:ubiquinone oxidoreductase subunit A11 | -8.686 | enzyme |
17 | IGSF6 | immunoglobulin superfamily member 6 | -8.712 | transmembrane receptor |
18 | TNFRSF1B | TNF receptor superfamily member 1B | -8.746 | transmembrane receptor |
19 | PRPF18 | pre-mRNA processing factor 18 | -8.777 | transporter |
20 | SERP1 | stress associated endoplasmic reticulum protein 1 | -8.872 | other |
21 | UBE2J1 | ubiquitin conjugating enzyme E2 J1 | -8.874 | enzyme |
22 | VEGFA | vascular endothelial growth factor A | -8.933 | growth factor |
23 | GYS1 | glycogen synthase 1 | -9.027 | enzyme |
24 | GPR65 | G protein-coupled receptor 65 | -9.054 | G-protein coupled receptor |
25 | ILF2 | interleukin enhancer binding factor 2 | -9.105 | transcription regulator |
26 | OSBPL11 | oxysterol binding protein like 11 | -9.201 | other |
27 | PSMA5 | proteasome subunit alpha 5 | -9.31 | peptidase |
28 | PIAS1 | protein inhibitor of activated STAT 1 | -9.326 | transcription regulator |
29 | TRAF7 | TNF receptor associated factor 7 | -9.341 | enzyme |
30 | COX14 | COX14, cytochrome c oxidase assembly factor | -9.447 | other |
31 | RPS26 | ribosomal protein S26 | -9.456 | other |
32 | SFPQ | splicing factor proline and glutamine rich | -9.469 | other |
33 | ATF4 | activating transcription factor 4 | -9.515 | transcription regulator |
34 | PECAM1 | platelet and endothelial cell adhesion molecule 1 | -9.552 | other |
35 | GPS2 | G protein pathway suppressor 2 | -9.56 | transcription regulator |
36 | NFIL3 | nuclear factor, interleukin 3 regulated | -9.568 | transcription regulator |
37 | PSMB8 | proteasome subunit beta 8 | -9.709 | peptidase |
38 | UBP1 | upstream binding protein 1 (LBP-1a) | -9.718 | transcription regulator |
39 | RAP2C | RAP2C, member of RAS oncogene family | -9.792 | enzyme |
40 | PIBF1 | progesterone immunomodulatory binding factor 1 | -9.876 | other |
41 | USP25 | ubiquitin specific peptidase 25 | -9.911 | peptidase |
42 | FRS2 | fibroblast growth factor receptor substrate 2 | -9.962 | kinase |
43 | PSMB4 | proteasome subunit beta 4 | -10.119 | peptidase |
44 | USP15 | ubiquitin specific peptidase 15 | -10.16 | peptidase |
45 | UBA52 | ubiquitin A-52 residue ribosomal protein fusion product 1 | -10.176 | enzyme |
46 | UBE4A | ubiquitination factor E4A | -10.189 | enzyme |
47 | GTPBP8 | GTP binding protein 8 (putative) | -10.19 | other |
48 | USP19 | ubiquitin specific peptidase 19 | -10.713 | peptidase |
49 | TNFAIP8 | TNF alpha induced protein 8 | -10.974 | other |
50 | HSPA14 | heat shock protein family A (Hsp70) member 14 | -10.978 | peptidase |
51 | TLR8 | toll like receptor 8 | -11.975 | transmembrane receptor |
52 | IL27RA | interleukin 27 receptor subunit alpha | -12.004 | transmembrane receptor |
53 | SCP2 | sterol carrier protein 2 | -13.672 | transporter |
54 | IFNGR2 | interferon gamma receptor 2 | -13.844 | transmembrane receptor |
55 | ID2 | inhibitor of DNA binding 2, HLH protein | -14.133 | transcription regulator |
56 | TUSC2 | tumor suppressor candidate 2 | -15.922 | other |
57 | IL2RG | interleukin 2 receptor subunit gamma | -16.787 | transmembrane receptor |
58 | IL1R2 | interleukin 1 receptor type 2 | -19.547 | transmembrane receptor |
59 | IRF2 | interferon regulatory factor 2 | -22.655 | transcription regulator |
60 | PTGS2 | prostaglandin-endoperoxide synthase 2 | -25.841 | enzyme |
61 | mir-877 | microRNA 877 | -4497.07 | microRNA |
62 | mir-1250 | microRNA 1250 | -4755.79 | microRNA |
63 | mir-140 | microRNA 140 | -5668.259 | microRNA |
64 | KLRC4-KLRK1/KLRK1 | killer cell lectin like receptor K1 | -1565687.642 | transmembrane receptor |