Skip to main content

Table 3 Effect of δ-tocotrienol on down-regulation of fold change gene expression of “Molecules” section (64) of IPA analysis in hepatitis C patients

From: δ-Tocotrienol feeding modulates gene expression of EIF2, mTOR, protein ubiquitination through multiple-signaling pathways in chronic hepatitis C patients

Down-regulation
# Symbol Entrez Gene Name Expr Fold Change Type(s)
1 ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 -8.014 transporter
2 HSP90AB1 heat shock protein 90 alpha family class B member 1 -8.049 enzyme
3 APOBEC3A apolipoprotein B mRNA editing enzyme catalytic subunit 3A -8.163 enzyme
4 CXCR2 C-X-C motif chemokine receptor 2 -8.208 G-protein coupled receptor
5 IL16 interleukin 16 -8.239 cytokine
6 PSMC3 proteasome 26S subunit, ATPase 3 -8.346 transcription regulator
7 NDUFB9 NADH:ubiquinone oxidoreductase subunit B9 -8.354 enzyme
8 CYB5R4 cytochrome b5 reductase 4 -8.367 enzyme
9 ATG3 autophagy related 3 -8.376 enzyme
10 CREB1 cAMP responsive element binding protein 1 -8.452 transcription regulator
12 NDUFB1 NADH:ubiquinone oxidoreductase subunit B1 -8.566 enzyme
13 PDE3B phosphodiesterase 3B -8.568 enzyme
14 IGF2R insulin like growth factor 2 receptor -8.68 transmembrane receptor
15 CYP2R1 cytochrome P450 family 2 subfamily R member 1 -8.682 enzyme
16 NDUFA11 NADH:ubiquinone oxidoreductase subunit A11 -8.686 enzyme
17 IGSF6 immunoglobulin superfamily member 6 -8.712 transmembrane receptor
18 TNFRSF1B TNF receptor superfamily member 1B -8.746 transmembrane receptor
19 PRPF18 pre-mRNA processing factor 18 -8.777 transporter
20 SERP1 stress associated endoplasmic reticulum protein 1 -8.872 other
21 UBE2J1 ubiquitin conjugating enzyme E2 J1 -8.874 enzyme
22 VEGFA vascular endothelial growth factor A -8.933 growth factor
23 GYS1 glycogen synthase 1 -9.027 enzyme
24 GPR65 G protein-coupled receptor 65 -9.054 G-protein coupled receptor
25 ILF2 interleukin enhancer binding factor 2 -9.105 transcription regulator
26 OSBPL11 oxysterol binding protein like 11 -9.201 other
27 PSMA5 proteasome subunit alpha 5 -9.31 peptidase
28 PIAS1 protein inhibitor of activated STAT 1 -9.326 transcription regulator
29 TRAF7 TNF receptor associated factor 7 -9.341 enzyme
30 COX14 COX14, cytochrome c oxidase assembly factor -9.447 other
31 RPS26 ribosomal protein S26 -9.456 other
32 SFPQ splicing factor proline and glutamine rich -9.469 other
33 ATF4 activating transcription factor 4 -9.515 transcription regulator
34 PECAM1 platelet and endothelial cell adhesion molecule 1 -9.552 other
35 GPS2 G protein pathway suppressor 2 -9.56 transcription regulator
36 NFIL3 nuclear factor, interleukin 3 regulated -9.568 transcription regulator
37 PSMB8 proteasome subunit beta 8 -9.709 peptidase
38 UBP1 upstream binding protein 1 (LBP-1a) -9.718 transcription regulator
39 RAP2C RAP2C, member of RAS oncogene family -9.792 enzyme
40 PIBF1 progesterone immunomodulatory binding factor 1 -9.876 other
41 USP25 ubiquitin specific peptidase 25 -9.911 peptidase
42 FRS2 fibroblast growth factor receptor substrate 2 -9.962 kinase
43 PSMB4 proteasome subunit beta 4 -10.119 peptidase
44 USP15 ubiquitin specific peptidase 15 -10.16 peptidase
45 UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -10.176 enzyme
46 UBE4A ubiquitination factor E4A -10.189 enzyme
47 GTPBP8 GTP binding protein 8 (putative) -10.19 other
48 USP19 ubiquitin specific peptidase 19 -10.713 peptidase
49 TNFAIP8 TNF alpha induced protein 8 -10.974 other
50 HSPA14 heat shock protein family A (Hsp70) member 14 -10.978 peptidase
51 TLR8 toll like receptor 8 -11.975 transmembrane receptor
52 IL27RA interleukin 27 receptor subunit alpha -12.004 transmembrane receptor
53 SCP2 sterol carrier protein 2 -13.672 transporter
54 IFNGR2 interferon gamma receptor 2 -13.844 transmembrane receptor
55 ID2 inhibitor of DNA binding 2, HLH protein -14.133 transcription regulator
56 TUSC2 tumor suppressor candidate 2 -15.922 other
57 IL2RG interleukin 2 receptor subunit gamma -16.787 transmembrane receptor
58 IL1R2 interleukin 1 receptor type 2 -19.547 transmembrane receptor
59 IRF2 interferon regulatory factor 2 -22.655 transcription regulator
60 PTGS2 prostaglandin-endoperoxide synthase 2 -25.841 enzyme
61 mir-877 microRNA 877 -4497.07 microRNA
62 mir-1250 microRNA 1250 -4755.79 microRNA
63 mir-140 microRNA 140 -5668.259 microRNA
64 KLRC4-KLRK1/KLRK1 killer cell lectin like receptor K1 -1565687.642 transmembrane receptor