Table 4 Effect of δ-tocotrienol on up-regulation (24) of fold change gene expression in "causal netwworks" section of IPA analysis in hepatitis C patients
# | Master Regulator | Molecule Type | Part. regulators1 | Depth | Pred Acti State2 | Act. Z-Score3 | P-Value Over4 | Network Bi-Corr5 | Causal Net6 | Target-Con-Re7 |
|---|---|---|---|---|---|---|---|---|---|---|
A | Up-regulation | |||||||||
1 | leuprolide | biologic drug | 26s Proteasome,AKT1 | 3 | Activated | 2.104 | 8.5E-10 | 0.0032 | 217 (71) | 69 |
2 | HLA-DR | complex | 26s Proteasome,AR,ATR | 3 | Activated | 5.458 | 3.44E-09 | 0.0145 | 260 (87) | 86 |
3 | PRDX1 | enzyme | 26s Proteasome,ABL1 | 3 | Activated | 7.084 | 1.73E-08 | 0.0427 | 250 (76) | 75 |
4 | alefacept | bilologic drug | alefacept, AP1,CD2 | 3 | Activated | 2.278 | 2.50E-07 | 0.0222 | 85 (20) | 20 |
5 | juglone | chemical toxicant | CASP3,FOS,juglone,JUN | 2 | Activated | 2.449 | 0.00000682 | 0.0272 | 54 (9) | 9 |
6 | mir-148 | microRNA | mir-148 | 1 | Activated | 2.000 | 0.00103 | 0.0055 | 4 (1) | 1 |
7 | 26s Proteasome | complex | 26s Proteasome | 1 | Activated | 2.840 | 0.00167 | 0.0476 | 15 (1) | 1 |
8 | mir-122 | microRNA | mir-122 | 1 | Activated | 3.317 | 0.00189 | 0.022 | 11 (1) | 1 |
9 | mir-19 | microRNA | mir-19 | 1 | Activated | 2.236 | 0.002 | 0.0185 | 5 (1) | 1 |
10 | mir-9 | microRNA | mir-9 | 1 | Activated | 2.000 | 0.00473 | 0.0203 | 4 (1) | 1 |
11 | IL2RG | transmembrane | IL2RG | 1 | Activated | 0.000 | 0.00181 | 0.0188 | 8 (1) | 1 |
12 | miR-2682-5p (other miRNAs w/seed AGGC) | mature microRNA | miR-2682-5p (miRNAs) | 1 | Activated | 1.414 | 0.00584 | 0.0073 | 2 (1) | 1 |
13 | alpha-tocopherol succinate | chemical drug | alpha-tocopherol succinate | 1 | Activated | 0.000 | 0.00597 | 0.0316 | 4 (1) | 1 |
14 | mir-199 | microRNA | mir-199 | 1 | Activated | 1.732 | 0.00849 | 0.0258 | 3 (1) | 1 |
15 | mir-138 | microRNA | mir-138 | 1 | Activated | 1.414 | 0.0113 | 0.0239 | 2 (1) | 1 |
16 | miR-330-5p (other miRNAs w/seed CUCU) | mature microRNA | miR-330-5p (and other | 1 | Activated | 1.414 | 0.0113 | 0.0209 | 2 (1) | 1 |
17 | mir-326 | microRNA | mir-326 | 1 | Activated | 1.414 | 0.0113 | 0.0191 | 2 (1) | 1 |
18 | mir-32 | microRNA | mir-32 | 1 | Activated | 1.414 | 0.0113 | 0.0304 | 2 (1) | 1 |
19 | LAMP2 | enzyme | LAMP2 | 1 | Activated | 0.000 | 0.0113 | 0.0251 | 2 (1) | 1 |
20 | mir-218 | microRNA | mir-218 | 1 | Activated | 1.732 | 0.0183 | 0.0398 | 3 (1) | 1 |
21 | UBA7 | enzyme | UBA7 | 1 | Activated | 1.414 | 0.0183 | 0.0416 | 2 (1) | 1 |
22 | miR-147a (miRNAs w/seed UGUGUGG) | mature microRNA | miR-147a (other miRNAs) | 1 | Activated | 1.000 | 0.0448 | 0.0417 | 1 (1) | 1 |
23 | miR-504-5p (other miRNAs w/seed GACC) | mature microRNA | miR-504-5p (miRNAs) | 1 | Activated | 1.000 | 0.0448 | 0.0417 | 1 (1) | 1 |
24 | BI 2536 | chemical drug | 26s Proteasome,ABL1 | 3 | Activated | 1.331 | 2.06E-12 | 0.0034 | 249 (50) | 49 |