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Table 4 Effect of δ-tocotrienol on up-regulation (24) of fold change gene expression in "causal netwworks" section of IPA analysis in hepatitis C patients

From: δ-Tocotrienol feeding modulates gene expression of EIF2, mTOR, protein ubiquitination through multiple-signaling pathways in chronic hepatitis C patients

# Master Regulator Molecule Type Part. regulators1 Depth Pred Acti State2 Act. Z-Score3 P-Value Over4 Network Bi-Corr5 Causal Net6 Target-Con-Re7
A Up-regulation          
1 leuprolide biologic drug 26s Proteasome,AKT1 3 Activated 2.104 8.5E-10 0.0032 217 (71) 69
2 HLA-DR complex 26s Proteasome,AR,ATR 3 Activated 5.458 3.44E-09 0.0145 260 (87) 86
3 PRDX1 enzyme 26s Proteasome,ABL1 3 Activated 7.084 1.73E-08 0.0427 250 (76) 75
4 alefacept bilologic drug alefacept, AP1,CD2 3 Activated 2.278 2.50E-07 0.0222 85 (20) 20
5 juglone chemical toxicant CASP3,FOS,juglone,JUN 2 Activated 2.449 0.00000682 0.0272 54 (9) 9
6 mir-148 microRNA mir-148 1 Activated 2.000 0.00103 0.0055 4 (1) 1
7 26s Proteasome complex 26s Proteasome 1 Activated 2.840 0.00167 0.0476 15 (1) 1
8 mir-122 microRNA mir-122 1 Activated 3.317 0.00189 0.022 11 (1) 1
9 mir-19 microRNA mir-19 1 Activated 2.236 0.002 0.0185 5 (1) 1
10 mir-9 microRNA mir-9 1 Activated 2.000 0.00473 0.0203 4 (1) 1
11 IL2RG transmembrane IL2RG 1 Activated 0.000 0.00181 0.0188 8 (1) 1
12 miR-2682-5p (other miRNAs w/seed AGGC) mature microRNA miR-2682-5p (miRNAs) 1 Activated 1.414 0.00584 0.0073 2 (1) 1
13 alpha-tocopherol succinate chemical drug alpha-tocopherol succinate 1 Activated 0.000 0.00597 0.0316 4 (1) 1
14 mir-199 microRNA mir-199 1 Activated 1.732 0.00849 0.0258 3 (1) 1
15 mir-138 microRNA mir-138 1 Activated 1.414 0.0113 0.0239 2 (1) 1
16 miR-330-5p (other miRNAs w/seed CUCU) mature microRNA miR-330-5p (and other 1 Activated 1.414 0.0113 0.0209 2 (1) 1
17 mir-326 microRNA mir-326 1 Activated 1.414 0.0113 0.0191 2 (1) 1
18 mir-32 microRNA mir-32 1 Activated 1.414 0.0113 0.0304 2 (1) 1
19 LAMP2 enzyme LAMP2 1 Activated 0.000 0.0113 0.0251 2 (1) 1
20 mir-218 microRNA mir-218 1 Activated 1.732 0.0183 0.0398 3 (1) 1
21 UBA7 enzyme UBA7 1 Activated 1.414 0.0183 0.0416 2 (1) 1
22 miR-147a (miRNAs w/seed UGUGUGG) mature microRNA miR-147a (other miRNAs) 1 Activated 1.000 0.0448 0.0417 1 (1) 1
23 miR-504-5p (other miRNAs w/seed GACC) mature microRNA miR-504-5p (miRNAs) 1 Activated 1.000 0.0448 0.0417 1 (1) 1
24 BI 2536 chemical drug 26s Proteasome,ABL1 3 Activated 1.331 2.06E-12 0.0034 249 (50) 49
  1. 1Part. Regulators = Paticipating Regulators; 2Pred Acti state = Predicted Acitivation State; 3Act. Z-Score = Activation Z-Score; 4P-Value Over. = P-Value Overlap; 5Network Bi-Corr = Network Bias-Corrected P-Values; 7Target-Con-Re. = Target Connected regulators