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Table 8 Effect of δ-tocotrienol on down-regulation of fold change expression in “upstream regulators” section (64) of IPA analysis in hepatitis C patients

From: δ-Tocotrienol feeding modulates gene expression of EIF2, mTOR, protein ubiquitination through multiple-signaling pathways in chronic hepatitis C patients

# Upstream Regulator Molecule Type Predicted Activation State Activation z-score p-value of overlap Mechanistic Network
Down-regulated
1 interferon beta-1a biologic drug    9.17E-14  
2 IL2 cytokine Inhibited -4.562 2.23E-09 297 (17)
3 IL15 cytokine Inhibited -2.247 1.37E-08 299 (19)
4 FAS transmembrane receptor   -1.461 3.94E-08 263 (17)
5 TNF cytokine Inhibited -5.914 0.000000294 378 (19)
6 IL21 cytokine Inhibited -2.747 0.00000339 264 (15)
7 GATA1 transcription regulator   -0.822 0.00000497 243 (11)
8 IRF1 transcription regulator Inhibited -3.223 0.000011 245 (13)
9 EGF growth factor Inhibited -5.15 0.0000204 303 (15)
10 TGFB1 growth factor Inhibited -3.491 0.00004 350 (17)
11 IL6 cytokine Inhibited -3.043 0.0000566 284 (15)
12 IL5 cytokine Inhibited -4.866 0.0000654 243 (13)
13 Interferon alpha group Inhibited -4.069 0.000154 150 (9)
14 STAT4 transcription regulator Inhibited -4.536 0.000489 111 (6)
15 IL7 cytokine Inhibited -2.665 0.00064 243 (18)
16 IL13 cytokine   -1.516 0.000806 295 (16)
17 STAT1 transcription regulator Inhibited -4.582 0.000877 241 (14)
18 IL1B cytokine Inhibited -4.367 0.000982 330 (17)
19 STAT2 transcription regulator Inhibited -2.219 0.00105 173 (9)
20 PARP9 enzyme Inhibited -2.200 0.00123 142 (6)
21 FOXC1 transcription regulator   -1.961 0.002  
22 IL2RG transmembrane receptor   -0.113 0.00233  
23 IL12 (complex) complex Inhibited -2.378 0.00251 246 (17)
24 TGFA growth factor Inhibited -2.888 0.00327 283 (17)
25 CD14 transmembrane receptor   -1.768 0.00332 298 (16)
26 TNFSF10 cytokine   -1.376 0.00477 297 (17)
27 mir-223 microrna Inhibited -2.060 0.00527 167 (7)
28 IL27 cytokine Inhibited -2.937 0.00527 317 (16)
29 beta-estradiol chemical - endogenous mammalian Inhibited -4.574 0.00546 358 (17)
30 IL10 cytokine   -0.803 0.00582 247 (17)
31 ADORA2A g-protein coupled receptor Inhibited -2.365 0.00599 175 (9)
32 IFNL1 cytokine Inhibited -2.925 0.00622 224 (11)
33 IL18 cytokine Inhibited -2.26 0.00701 326 (19)
34 NOX1 ion channel   -1.951 0.00741 263 (14)
35 SOX4 transcription regulator Inhibited -3.033 0.00834  
36 prostaglandin J2 chemical - endogenous non-mammalian   -1.432 0.0115  
37 E2F1 transcription regulator Inhibited -2.081 0.0142  
38 CREB1 transcription regulator Inhibited -3.766 0.0143  
39 IGF1 growth factor Inhibited -2.385 0.0158  
40 IL12 (family) group   -0.500 0.016  
41 IRF5 transcription regulator Inhibited -2.155 0.0162  
42 FOXO4 transcription regulator   -1.98 0.0179  
43 PGF growth factor   -1.959 0.0237  
44 BTG2 transcription regulator   1.165 0.0239  
45 mir-15 microrna   -0.927 0.0279  
46 STAT5A transcription regulator   -0.896 0.0294  
47 NFE2L2 transcription regulator Inhibited -3.644 0.0295  
48 MIF cytokine Inhibited -2.642 0.0304  
49 FGF10 growth factor Inhibited -2.200 0.0305  
50 miR-26a-5p (and other miRNAs w/seed UCAAGUA) mature microrna   1.916 0.0309  
51 NOX4 enzyme   -1.941 0.0309  
52 NFKBIB transcription regulator   -1.400 0.0331  
53 IFNA1/IFNA13 cytokine   -1.77 0.0331  
54 FLT3LG cytokine Inhibited -2.411 0.0331  
55 IL17F cytokine   -1.917 0.0349  
56 IL32 cytokine   -1.15 0.0416  
57 CCL5 cytokine Inhibited -2.621 0.042  
58 IL17A cytokine Inhibited -3.075 0.0422  
59 MIR124 group   1.941 0.0435  
60 miR-218-5p (and other miRNAs w/seed UGUGCUU) mature microrna    0.0443  
61 CXCR4 g-protein coupled receptor   -0.842 0.0447  
62 CD38 enzyme Inhibited -3.429 0.0482  
63 IL24 cytokine   -0.277 0.0498  
64 TCF3 transcription regulator Inhibited -2.530 0.231