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Table 2 Univariate Analysis of Possible Influencing Factors of the Risk of Biopsy-induced Bleeding

From: Plasma apolipoprotein E level is associated with the risk of endobronchial biopsy-induced bleeding in patients with lung cancer

Variables Biopsy-induced Bleeding
OR (95% CI) P value
Age (y), median (range) 1.01 (0.99, 1.03) 0.1909
Sex, n (%)
 Female Ref.  
 Man 1.41 (0.94, 2.13) 0.0990
Smoking, n (%)
 Never Ref.  
 Former 1.83 (1.12, 2.97) 0.0153
 Current 1.47 (1.02, 2.13) 0.0411
SBP (mmHg) 0.99 (0.99, 1.00) 0.1595
DBP (mmHg) 1.00 (0.99, 1.02) 0.5100
Location of lesion, n (%)
 Peripheral bronchi Ref.  
 Central airway 3.50 (2.13, 5.72) < 0.0001
Stage, n (%)
 Early Ref.  
 Advanced 1.88 (1.35, 2.63) 0.0002
Histological types, n (%)
 Adenocarcinoma Ref.  
 Squamous cell carcinoma 2.77 (1.79, 4.26) < 0.0001
 SCLC 2.21 (1.29, 3.78) 0.0037
 Others 2.47 (1.11, 5.48) 0.0260
COPD, n (%)
 No Ref.  
 Yes 1.08 (0.57, 2.06) 0.8155
Hypertension, n (%)
 No Ref.  
 Yes 1.10 (0.76, 1.61) 0.6085
Diabetes, n (%)
 No Ref.  
 Yes 0.82 (0.38, 1.78) 0.6214
CHD, n (%)
 No Ref.  
 Yes 1.17 (0.47, 2.91) 0.7356
Triglyceride (mmol/L) 0.80 (0.61, 1.05) 0.1084
TC (mmol/L) 0.91 (0.77, 1.07) 0.2707
HDLC (mmol/L) 0.52 (0.31, 0.88) 0.0146
LDLC (mmol/L) 0.89 (0.71, 1.11) 0.2856
Apo E (mg/dL) 0.89 (0.80, 1.00) 0.0488
Apo B (g/L) 0.76 (0.46, 1.27) 0.2949
Homocysteine (μmol/L) 1.00 (0.99, 1.01) 0.4514
WBC (×109/L) 1.03 (0.98, 1.08) 0.2423
Neutrophils (×109/L) 1.04 (0.99, 1.10) 0.0856
Hemoglobin (g/L) 1.00 (0.99, 1.00) 0.7850
platelets (× 109/L) 1.00 (1.00, 1.00) 0.1130
CRP (mg/L) 1.01 (1.00, 1.01) 0.0093
PT (S) 0.99 (0.98, 1.01) 0.2445
APTT (S) 0.99 (0.98, 1.00) 0.1430
ALT (IU/L) 1.00 (0.99, 1.01) 0.6193
AST (IU/L) 1.00 (0.99, 1.01) 0.9870
  1. SBP systolic blood pressure, DBP diastolic blood pressure, SCLC small-cell lung carcinoma, COPD Chronic obstructive pulmonary disease, CHD coronary heart disease, TC total cholesterol, HDLC high density lipoprotein cholesterol, LDLC low density lipoprotein cholesterol, Apo apolipoprotein, WBC white blood cell, CRP C-reactive protein, PT prothrombin time, APTT activated partial thromboplastin time, ALT alanine aminotransferase, AST aspartate aminotransferase