Fig. 9

Synthesis of skin surface lipids of sebaceous origin, derived from Smith and Thiboutot [42] and Zouboulis [37] Lipids are synthesised in the sebaceous glands from the substrates, some of which are acquired from the blood circulation. Lipid synthesis in the sebaceous cells (sebocytes) is controlled by various enzymes (indicated by boxes shaded in green). Lipid composition in the glands is different from that on the skin surface as triglycerides are hydrolysed by lipase to liberate free fatty acids and diglycerides on the skin surface. *The examples of receptors present in the sebocytes are listed in Table 2. DGAT- diacylglycerol acyltransferase, FATP- fatty acid transport protein, LDL- low-density lipoprotein