Association of LIPC -250G/A and -514C/T polymorphisms and hypertension: a systematic review and meta-analysis

Table 3 The results of meta-analysis

SNP	Gene model	Sample size			Test of association			Model	Test of heterogeneity^a,b			Publication bias^c
SNP	Gene model	K	Cases	Control	OR (95% CI)	Z	P	Model	Q	P	I² (%)	t	P value
rs1800588	T VS. C	3	1162	1188	0.9276 [0.7838; 1.0979]	0.87	0.3822	F	2.93	0.23	31.7	1.0914	0.4722
	CT VS. CC	3	486	492	0.9090 [0.7038; 1.1741]	0.73	0.4649	F	0.30	0.86	0.0	0.5385	0.6855
	TT VS. CC	3	323	319	0.7446 [0.3839; 1.4441]	0.87	0.3829	R	5.13	0.08	61.0	2.2042	0.2711
	TT VS. CC + CT	3	581	594	0.8176 [0.4286; 1.5597]	0.61	0.5412	R	6.26	0.04	68.1	2.9604	0.2074
	TT + CT VS. CC	3	581	594	0.8882 [0.6974; 1.1312]	0.96	0.3369	F	0.41	0.81	0.00	1.7230	0.3348
rs2070895	A VS. G	3	1982	2026	1.2428 [0.9664; 1.5982]	1.69	0.0903	R	7.51	0.02	73.4	0.5956	0.6580
	AA VS. GG	3	541	540	1.7723 [0.8570; 3.6651]	1.54	0.1226	R	12.07	< 0.01	83.4	0.1520	0.9040
	AA VS. GG + GA	3	991	1013	1.7115 [0.8225; 3.5612]	1.44	0.1506	R	13.92	< 0.01	85.6	0.1266	0.9198
	AA+GA VS. GG	3	991	1013	1.1954 [1.0001; 1.4288]	1.96	0.0498	F	3.80	0.15	47.4	1.0798	0.4756
	GA VS. GG	3	837	912	1.0693 [0.8128; 1.4067]	0.48	0.6319	R	4.22	0.12	52.6	0.7105	0.6068

OR Odds ratio, CI confidence interval, K The number of included studies, R Random, F Fixed
^aRandom-effects model was used when the P for heterogeneity test< 0.05, otherwise the fixed-effect model was used. ^bP < 0.05 is considered statistically significant for Q statistics. ^cEgger‘s test to evaluate publication bias, P < 0.05 is considered statistically significant

ISSN: 1476-511X